Kötke, Danijela; Gandrass, Juergen; Xie, Zhiyong; Ebinghaus, Ralf (2021): Prioritised pharmaceuticals in German estuaries and coastal waters in 2015/2016 [dataset]. PANGAEA, https://doi.org/10.1594/PANGAEA.929500
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Published: 2021-03-22 • DOI registered: 2021-05-20
Abstract:
In this study a target analysis approach with method detection limits down to 0.01 ng L−1 was developed in order to determine ultra-trace pharmaceuticals in seawater of the German coast and their estuaries. The selection of target analytes based on a prioritisation commissioned by the German Environmental Agency considering occurrence in German surface waters, production volumes and ecotoxicological data. Using ultra-high pressure liquid chromatography coupled to a triple quadrupole mass spectrometer equipped with an electrospray ionisation source 21 prioritised pharmaceuticals out of seven therapeutical classes (antibiotics, iodinated X-ray contrast media (ICM), analgesics, lipid reducers, antiepileptics, anticonvulsants, beta-blockers) have been detected in the low to medium ng L−1-range. The most frequently measured substance groups in the German Baltic Sea and German Bight are the ICM, represented by the non-ionic ICM iomeprol (German Bightmax: 207 ng L−1; Baltic Seamax: 34.5 ng L−1) and the ionic ICM amidotrizoic acid (German Bight: 86.9 ng L−1), respectively. The same pattern of substance distribution could be detected in the German Bight, the German Baltic Sea and their inflows with lower concentrations in the offshore region that are partly a result of dilution with marine water. Pharmaceuticals entering the estuaries and coastal regions are an environmental issue since data on the ecotoxicological effects on aquatic marine organisms is limited. Especially the antibiotics clarithromycin and sulfamethoxazole could be ecotoxicologically/environmentally critical.
Related to:
Kötke, Danijela; Gandrass, Juergen; Xie, Zhiyong; Ebinghaus, Ralf (2019): Prioritised pharmaceuticals in German estuaries and coastal waters: Occurrence and environmental risk assessment. Environmental Pollution, 255, 113161, https://doi.org/10.1016/j.envpol.2019.113161
Project(s):
Coverage:
Median Latitude: 54.066199 * Median Longitude: 11.016778 * South-bound Latitude: 53.036000 * West-bound Longitude: 8.078000 * North-bound Latitude: 54.823000 * East-bound Longitude: 14.535000
Date/Time Start: 2015-05-29T12:00:00 * Date/Time End: 2016-03-16T16:40:00
Minimum DEPTH, water: 0 m * Maximum DEPTH, water: 0 m
Event(s):
LP20150529_Stat_E1 * Latitude: 53.843000 * Longitude: 8.941000 * Date/Time: 2015-06-02T11:40:00 * Location: German Bight, North Sea * Campaign: LP20150529 * Basis: Ludwig Prandtl * Method/Device: Water sample (WS)
LP20150529_Stat_E2 * Latitude: 53.874000 * Longitude: 9.238000 * Date/Time: 2015-06-02T12:35:00 * Location: German Bight, North Sea * Campaign: LP20150529 * Basis: Ludwig Prandtl * Method/Device: Water sample (WS)
LP20150529_Stat_E3 * Latitude: 53.745000 * Longitude: 9.407000 * Date/Time: 2015-06-02T13:30:00 * Location: German Bight, North Sea * Campaign: LP20150529 * Basis: Ludwig Prandtl * Method/Device: Water sample (WS)
Comment:
Date/Time = local time
Temperature, water; Salinity and pH method:For campaigns SB1603 and SB1508: oxygen, conductivity, temperature, pH; Multimeter 3430 WTW. For campaign LP20150529: Measurement by on-line-in-situ FerryBox-System.
Parameter(s):
| # | Name | Short Name | Unit | Principal Investigator | Method/Device | Comment |
|---|---|---|---|---|---|---|
| 1 | Event label | Event | Kötke, Danijela | |||
| 2 | Campaign of event | Campaign | Kötke, Danijela | |||
| 3 | Latitude of event | Latitude | Kötke, Danijela | |||
| 4 | Longitude of event | Longitude | Kötke, Danijela | |||
| 5 | Date/Time of event | Date/Time | Kötke, Danijela | |||
| 6 | DEPTH, water | Depth water | m | Kötke, Danijela | Geocode | |
| 7 | Temperature, water | Temp | °C | Kötke, Danijela | See description in dataset comment | measured in water column |
| 8 | Salinity | Sal | Kötke, Danijela | See description in dataset comment | measured in water column | |
| 9 | pH | pH | Kötke, Danijela | See description in dataset comment | measured in water column | |
| 10 | Nadolol | Nadolol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.03ng/l |
| 11 | Paracetamol | Paracetamol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.14ng/l, limit of quantification for SB1603 and SB1508: 0.03ng/l, limit of quantification for LP20150529: 0.46ng/l |
| 12 | Carbamazepine | Carbamazepine | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.11ng/l, limit of detection for LP20150529: 0.33ng/l, limit of quantification for SB1603 and SB1508: 0.38ng/l, limit of quantification for LP20150529: 1.12ng/l |
| 13 | Diclofenac | Diclofenac | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.03ng/l, limit of detection for LP20150529: 0.18ng/l, limit of quantification for SB1603 and SB1508: 0.1ng/l, limit of quantification for LP20150529: 0.61ng/l |
| 14 | Iohexol | Iohexol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.17ng/l, limit of detection for LP20150529: 0.34ng/l, limit of quantification for SB1603 and SB1508: 0.26ng/l, limit of quantification for LP20150529: 0.53ng/l |
| 15 | Iopromide | Iopromide | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.17ng/l, limit of detection for LP20150529: 0.3ng/l, limit of quantification for SB1603 and SB1508: 0.27ng/l, limit of quantification for LP20150529: 0.85ng/l |
| 16 | Lincomycin | Lincomycin | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.01ng/l |
| 17 | Propranolol | Propranolol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.02ng/l, limit of detection for LP20150529: 0.03ng/l, limit of quantification for SB1603 and SB1508: 0.07ng/l, limit of quantification for LP20150529: 0.09ng/l |
| 18 | Sulfadimethoxine | Sulfadimethoxine | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.04ng/l |
| 19 | Sulfamethoxazole | Sulfamethoxazole | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.02ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.07ng/l |
| 20 | Bezafibrate | Bezafibrate | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.03ng/l, limit of detection for LP20150529: 0.06ng/l, limit of quantification for SB1603 and SB1508: 0.18ng/l, limit of quantification for LP20150529: 0.36ng/l |
| 21 | Clarithromycin | Clarithromycin | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.03ng/l |
| 22 | Erythromycin | Erythromycin | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.01ng/l |
| 23 | Iomeprol | Iomeprol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.16ng/l, limit of detection for LP20150529: 0.99ng/l, limit of quantification for SB1603 and SB1508: 0.4ng/l, limit of quantification for LP20150529: 3.29ng/l |
| 24 | Iopamidol | Iopamidol | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.15ng/l, limit of detection for LP20150529: 0.34ng/l, limit of quantification for SB1603 and SB1508: 0.34ng/l, limit of quantification for LP20150529: 0.53ng/l |
| 25 | Primidone | Primidone | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.04ng/l, limit of detection for LP20150529: 0.1ng/l, limit of quantification for SB1603 and SB1508: 0.13ng/l, limit of quantification for LP20150529: 0.34ng/l |
| 26 | Roxithromycin | Roxithromycin | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.02ng/l, limit of quantification for SB1603 and SB1508: 0.04ng/l, limit of quantification for LP20150529: 0.06ng/l |
| 27 | Sulfamethazine | Sulfamethazine | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.07ng/l, limit of detection for LP20150529: 0.33ng/l, limit of quantification for SB1603 and SB1508: 0.22ng/l, limit of quantification for LP20150529: 1.09ng/l |
| 28 | Tiamulin | Tiamulin | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.02ng/l |
| 29 | Amidotrizoic acid | Amidotrizoic acid | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for LP20150529: 0.05ng/l, limit of quantification for LP20150529: 0.35ng/l |
| 30 | Ioxitalamic acid | Ioxitalamic acid | ng/l | Kötke, Danijela | Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) | measured in water column, limit of detection for LP20150529: 0.06ng/l, limit of quantification for LP20150529: 0.36ng/l |
License:
Creative Commons Attribution 4.0 International (CC-BY-4.0)
Size:
1176 data points