Falfushynska, Halina; Sokolov, Eugene P; Haider, Fouzia; Oppermann, Christina; Kragl, Udo; Ruth, Wolfgang; Stock, Marius; Glufke, Sabrina; Winkel, Eileen J; Sokolova, Inna M (2019): Effect of atorvastatin on the xenobioitic detoxification of blue mussels, Mytilus edulis [dataset]. PANGAEA, https://doi.org/10.1594/PANGAEA.898930
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Published: 2019-03-04 • DOI registered: 2019-04-12
Abstract:
Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels – Mytilus edulis. In this data set, we presents the effect of atorvastatin (ATO) on detoxification of Mytilus edulis.
Related to:
Falfushynska, Halina; Sokolov, Eugene P; Haider, Fouzia; Oppermann, Christina; Kragl, Udo; Ruth, Wolfgang; Stock, Marius; Glufke, Sabrina; Winkel, Eileen J; Sokolova, Inna M (2019): Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis. Aquatic Toxicology, 208, 47-61, https://doi.org/10.1016/j.aquatox.2018.12.022
Parameter(s):
| # | Name | Short Name | Unit | Principal Investigator | Method/Device | Comment |
|---|---|---|---|---|---|---|
| 1 | Species | Species | Sokolova, Inna M | |||
| 2 | Treatment | Treat | Sokolova, Inna M | Exposure to Atorvastatin | ||
| 3 | Time in weeks | Time weeks | weeks | Sokolova, Inna M | Exposure time | |
| 4 | Sample ID | Sample ID | Sokolova, Inna M | |||
| 5 | Mytilus edulis, mass | M. edulis m | g | Sokolova, Inna M | Total body mass | |
| 6 | Rhodamine B efflux rate | RB efflux rate | nmol/h/g | Sokolova, Inna M | ||
| 7 | P-glycoprotein activity | PgP activity | nmol/h/g | Sokolova, Inna M | ||
| 8 | Comment | Comment | Sokolova, Inna M | PgP activity | ||
| 9 | Diffusion efflux rate | Diff efflux rate | nmol/h/g | Sokolova, Inna M | ||
| 10 | Comment | Comment | Sokolova, Inna M | Outlier |
License:
Creative Commons Attribution 4.0 International (CC-BY-4.0)
Size:
143 data points
Data
| 1 Species | 2 Treat (Exposure to Atorvastatin) | 3 Time weeks [weeks] (Exposure time) | 4 Sample ID | 5 M. edulis m [g] (Total body mass) | 6 RB efflux rate [nmol/h/g] | 7 PgP activity [nmol/h/g] | 8 Comment (PgP activity) | 9 Diff efflux rate [nmol/h/g] | 10 Comment (Outlier) |
|---|---|---|---|---|---|---|---|---|---|
| M. edulis | Control | 0 | C1-A | 0.893 | 8.614 | 0.000 | activity below detection limit | 11.160 | Outlier |
| M. edulis | Control | 0 | C1-B | 1.275 | 11.228 | 4.127 | 7.101 | ||
| M. edulis | Control | 0 | C1-C | 0.961 | 0.468 | 0.175 | 0.293 | ||
| M. edulis | Control | 0 | C1-D | 1.369 | 14.226 | 5.224 | 9.002 | ||
| M. edulis | Control | 0 | C1-E | 1.073 | 7.476 | 0.000 | activity below detection limit | 8.902 | Outlier |
| M. edulis | Control | 0 | C2-A | 1.648 | 21.732 | 13.008 | 8.723 | ||
| M. edulis | Control | 0 | C2-B | 1.284 | 14.696 | 7.650 | 7.047 | ||
| M. edulis | Control | 0 | C2-C | 1.370 | 7.034 | 5.242 | 1.791 | ||
| M. edulis | Control | 0 | C2-D | 1.453 | 7.668 | 0.000 | activity below detection limit | 9.295 | Outlier |
| M. edulis | Control | 0 | C2-E | 0.982 | 20.829 | 13.809 | 7.020 | ||
| M. edulis | Exposed | 4 | AS1-A | 1.675 | 4.245 | 0.100 | 4.144 | Outlier | |
| M. edulis | Exposed | 4 | AS1-B | 1.599 | 3.685 | 1.700 | 1.985 | ||
| M. edulis | Exposed | 4 | AS1-C | 1.369 | 3.050 | 1.192 | 1.858 | ||
| M. edulis | Exposed | 4 | AS1-D | 1.268 | 4.022 | 2.650 | 1.372 | ||
| M. edulis | Exposed | 4 | AS1-E | 0.949 | 4.761 | 2.415 | 2.346 | ||
| M. edulis | Exposed | 4 | AS2-A | 1.262 | 1.678 | 0.837 | 0.837 | ||
| M. edulis | Exposed | 4 | AS2-B | 1.052 | 3.844 | 2.082 | 2.082 |