Citation:

PANGAEA.898921

Name: Effect of atorvastatin on mitochondrial respiration of the blue mussels, Mytilus edulis
Published: 2019-03-04
License: https://creativecommons.org/licenses/by/4.0/
Keywords: Atorvastatin; mitochondrial respiration; Mytilus edulis

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Published: 2019-03-04 • DOI registered: 2019-04-12

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Abstract:

Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels – Mytilus edulis. In this data set, we presents the effect of atorvastatin (ATO) on mitochondrial respiration of Mytilus edulis.

Keyword(s):

Atorvastatin; mitochondrial respiration; Mytilus edulis

Related to:

Falfushynska, Halina; Sokolov, Eugene P; Haider, Fouzia; Oppermann, Christina; Kragl, Udo; Ruth, Wolfgang; Stock, Marius; Glufke, Sabrina; Winkel, Eileen J; Sokolova, Inna M (2019): Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis. Aquatic Toxicology, 208, 47-61, https://doi.org/10.1016/j.aquatox.2018.12.022

Parameter(s):

#	Name	Short Name	Unit	Principal Investigator	Comment
1	Species	Species		Haider, Fouzia
2	Treatment	Treat		Haider, Fouzia	Exposure to Atorvastatin
3	Time in weeks	Time weeks	weeks	Haider, Fouzia	Exposure time
4	Salinity	Sal		Haider, Fouzia	Acclimate salinity, psu
5	Temperature, water	Temp	°C	Haider, Fouzia	Acclimate temperature
6	Temperature, water	Temp	°C	Haider, Fouzia	Assay temperature
7	Sample ID	Sample ID		Haider, Fouzia
8	Tissues	Tissues		Haider, Fouzia
9	Tissue, wet mass	Tis WM	g	Haider, Fouzia
10	Mitochondrial suspension	Mitochondrial susp	ml	Haider, Fouzia
11	Buffer	Buffer	ml	Haider, Fouzia	Assay buffer
12	Osmolarity	Osm	mOsm	Haider, Fouzia	Assay Osmolarity
13	Proteins	Protein	mg/ml	Haider, Fouzia	mito suspension
14	Proteins	Protein	mg/ml	Haider, Fouzia	in assay
15	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with PM
16	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with Succ
17	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with ADP
18	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with Oligo
19	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with CCCP
20	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with Rotenon
21	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with Ant A
22	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with TMPD+Asc
23	Mitochondria, oxygen consumption	Mitochondria O2 con	µmol/g/min	Haider, Fouzia	with KCN
24	Ratio	Ratio		Haider, Fouzia	Respiratory control ratio

License:

Creative Commons Attribution 4.0 International (CC-BY-4.0)

Size:

528 data points

Data

Download dataset as tab-delimited text — use the following character encoding:

1 Species	2 Treat (Exposure to Atorvastatin)	3 Time weeks [weeks] (Exposure time)	4 Sal (Acclimate salinity, psu)	5 Temp [°C] (Acclimate temperature)	6 Temp [°C] (Assay temperature)	7 Sample ID	8 Tissues	9 Tis WM [g]	10 Mitochondrial susp [ml]	11 Buffer [ml] (Assay buffer)	12 Osm [mOsm] (Assay Osmolarity)	13 Protein [mg/ml] (mito suspension)	14 Protein [mg/ml] (in assay)	15 Mitochondria O2 con [µmol/g/min] (with PM)	16 Mitochondria O2 con [µmol/g/min] (with Succ)	17 Mitochondria O2 con [µmol/g/min] (with ADP)	18 Mitochondria O2 con [µmol/g/min] (with Oligo)	19 Mitochondria O2 con [µmol/g/min] (with CCCP)	20 Mitochondria O2 con [µmol/g/min] (with Rotenon)	21 Mitochondria O2 con [µmol/g/min] (with Ant A)	22 Mitochondria O2 con [µmol/g/min] (with TMPD+Asc)	23 Mitochondria O2 con [µmol/g/min] (with KCN)	24 Ratio (Respiratory control ratio)
Mytilus edulis	Control	0	15	15	15	Me ctr5	Digestive gland	0.41	0.2	1.95	450	6.343	0.590	3.181	3.961	8.981	2.257	12.040	9.633	0.891	23.661	3.812	3.595
Mytilus edulis	Control	0	15	15	27	Me ctr5	Digestive gland	0.41	0.1	2.00	450	6.343	0.302	5.604	6.662	16.266	5.043	19.816	14.593	1.645	38.996	6.724	3.297
Mytilus edulis	Control	0	15	15	15	Me ctr6	Digestive gland	0.67	0.2	1.95	450	8.586	0.799	3.840	5.345	13.711	2.447	14.647	12.111	0.939	38.159	2.187	5.521
Mytilus edulis	Control	0	15	15	27	Me ctr6	Digestive gland	0.67	0.1	2.00	450	8.586	0.409	16.188	9.127	25.896	6.642	27.264	22.922	1.605	48.407	4.029	3.681
Mytilus edulis	Control	0	15	15	15	Me ctr8	Digestive gland	0.45	0.2	1.95	450	6.702	0.623	2.832	3.336	7.861	2.236	9.655	7.981	0.722	19.366	2.294	3.519
Mytilus edulis	Control	0	15	15	27	Me ctr8	Digestive gland	0.45	0.1	2.00	450	6.702	0.319	11.089	6.336	13.187	5.468	19.909	14.446	0.828	28.575	3.554	2.137
Mytilus edulis	Control	0	15	15	15	Me ctr10	Digestive gland	0.50	0.2	1.95	450	4.970	0.462	7.193	10.595	25.585	4.716	25.828	13.605	1.133	33.240	4.217	5.179
Mytilus edulis	Control	0	15	15	27	Me ctr10	Digestive gland	0.50	0.1	2.00	450	4.970	0.237	20.831	10.684	21.482	8.493	40.930	30.512	2.520	53.014	15.006	2.424
Mytilus edulis	Control	0	15	15	15	Me ctr11	Digestive gland	0.41	0.2	1.95	450	3.094	0.288	8.419	5.099	11.273	3.632	15.019	11.931	2.029	27.907	4.371	3.115
Mytilus edulis	Control	0	15	15	27	Me ctr11	Digestive gland	0.41	0.1	2.00	450	3.094	0.147	20.971	11.296	23.435	8.478	26.203	16.579	2.971	39.710	16.386	2.605
Mytilus edulis	Exposed	4	15	15	15	Me stat1	Digestive gland	0.51	0.2	1.95	450	3.094	0.288	5.784	6.832	17.643	4.859	21.489	17.776	1.894	50.283	8.193	4.054
Mytilus edulis	Exposed	4	15	15	27	Me stat1	Digestive gland	0.51	0.1	2.00	450	3.094	0.147	9.133	12.702	41.074	10.057	52.072	39.442	3.036	84.568	10.214	3.977
Mytilus edulis	Exposed	4	15	15	15	Me stat2	Digestive gland	0.47	0.2	1.95	450	7.814	0.727	2.504	3.594	9.326	1.841	10.682	8.628	0.842	19.532	3.077	4.716
Mytilus edulis	Exposed	4	15	15	27	Me stat2	Digestive gland	0.47	0.1	2.00	450	7.814	0.372	9.491	4.498	7.493	3.856	18.095	15.598	1.135	28.198	6.453	1.721
Mytilus edulis	Exposed	4	15	15	15	Me stat4	Digestive gland	0.62	0.2	1.95	450	9.789	0.911	3.284	4.883	13.220	2.264	14.010	10.443	0.805	22.758	1.846	5.815
Mytilus edulis	Exposed	4	15	15	27	Me stat4	Digestive gland	0.62	0.1	2.00	450	9.789	0.466	4.274	6.418	17.332	4.981	25.922	18.405	0.416	32.127	2.202	3.334
Mytilus edulis	Exposed	4	15	15	15	Me stat5	Digestive gland	0.43	0.2	1.95	450	6.343	0.590	3.963	4.359	10.002	2.771	11.189	9.791	0.882	20.488	1.687	3.990
Mytilus edulis	Exposed	4	15	15	27	Me stat5	Digestive gland	0.43	0.1	2.00	450	6.343	0.302	11.571	7.171	15.536	6.082	20.945	16.284	1.834	28.062	4.162	2.274
Mytilus edulis	Exposed	4	15	15	15	Me stat7	Digestive gland	0.45	0.2	1.95	450	5.644	0.525	4.402	5.843	14.015	2.528	15.627	9.607	0.803	26.684	4.604	5.501
Mytilus edulis	Exposed	4	15	15	27	Me stat7	Digestive gland	0.45	0.1	2.00	450	5.644	0.269	5.791	7.977	24.254	5.836	30.563	19.391	0.638	41.023	4.219	4.162
Mytilus edulis	Exposed	4	15	15	15	Me stat3	Digestive gland	0.46	0.2	1.95	450	5.644	0.525	2.382	3.505	7.395	2.798	9.467	8.954	1.345	18.263	2.703	2.563
Mytilus edulis	Exposed	4	15	15	15	Me stat6	Digestive gland	0.36	0.2	1.95	450	6.702	0.623	3.533	3.570	7.719	2.324	9.352	7.930	1.634	12.287	2.219	3.214