/* DATA DESCRIPTION: Citation: Falfushynska, Halina; Sokolov, Eugene P; Haider, Fouzia; Oppermann, Christina; Kragl, Udo; Ruth, Wolfgang; Stock, Marius; Glufke, Sabrina; Winkel, Eileen J; Sokolova, Inna M (2019): Effect of atorvastatin on mitochondrial respiration of the blue mussels, Mytilus edulis [dataset]. PANGAEA, https://doi.org/10.1594/PANGAEA.898921 Abstract: Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels – Mytilus edulis. In this data set, we presents the effect of atorvastatin (ATO) on mitochondrial respiration of Mytilus edulis. Keyword(s): Atorvastatin; mitochondrial respiration; Mytilus edulis Related to: Falfushynska, Halina; Sokolov, Eugene P; Haider, Fouzia; Oppermann, Christina; Kragl, Udo; Ruth, Wolfgang; Stock, Marius; Glufke, Sabrina; Winkel, Eileen J; Sokolova, Inna M (2019): Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis. Aquatic Toxicology, 208, 47-61, https://doi.org/10.1016/j.aquatox.2018.12.022 Parameter(s): Species (Species) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) Treatment (Treat) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Exposure to Atorvastatin Time in weeks [weeks] (Time weeks) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Exposure time Salinity (Sal) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Acclimate salinity, psu Temperature, water [°C] (Temp) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Acclimate temperature Temperature, water [°C] (Temp) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Assay temperature Sample ID (Sample ID) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) Tissues (Tissues) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) Tissue, wet mass [g] (Tis WM) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) Mitochondrial suspension [ml] (Mitochondrial susp) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) Buffer [ml] (Buffer) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Assay buffer Osmolarity [mOsm] (Osm) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Assay Osmolarity Proteins [mg/ml] (Protein) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: mito suspension Proteins [mg/ml] (Protein) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: in assay Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with PM Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with Succ Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with ADP Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with Oligo Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with CCCP Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with Rotenon Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with Ant A Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with TMPD+Asc Mitochondria, oxygen consumption [µmol/g/min] (Mitochondria O2 con) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: with KCN Ratio (Ratio) * PI: Haider, Fouzia (https://orcid.org/0000-0002-5388-6453, fouzia.haider@uni-rostock.de) * COMMENT: Respiratory control ratio License: Creative Commons Attribution 4.0 International (CC-BY-4.0) (URI: https://creativecommons.org/licenses/by/4.0/) Size: 528 data points */ Species Treat (Exposure to Atorvastatin) Time weeks [weeks] (Exposure time) Sal (Acclimate salinity, psu) Temp [°C] (Acclimate temperature) Temp [°C] (Assay temperature) Sample ID Tissues Tis WM [g] Mitochondrial susp [ml] Buffer [ml] (Assay buffer) Osm [mOsm] (Assay Osmolarity) Protein [mg/ml] (mito suspension) Protein [mg/ml] (in assay) Mitochondria O2 con [µmol/g/min] (with PM) Mitochondria O2 con [µmol/g/min] (with Succ) Mitochondria O2 con [µmol/g/min] (with ADP) Mitochondria O2 con [µmol/g/min] (with Oligo) Mitochondria O2 con [µmol/g/min] (with CCCP) Mitochondria O2 con [µmol/g/min] (with Rotenon) Mitochondria O2 con [µmol/g/min] (with Ant A) Mitochondria O2 con [µmol/g/min] (with TMPD+Asc) Mitochondria O2 con [µmol/g/min] (with KCN) Ratio (Respiratory control ratio) Mytilus edulis Control 0 15 15 15 Me ctr5 Digestive gland 0.41 0.2 1.95 450 6.343 0.590 3.181 3.961 8.981 2.257 12.040 9.633 0.891 23.661 3.812 3.595 Mytilus edulis Control 0 15 15 27 Me ctr5 Digestive gland 0.41 0.1 2.00 450 6.343 0.302 5.604 6.662 16.266 5.043 19.816 14.593 1.645 38.996 6.724 3.297 Mytilus edulis Control 0 15 15 15 Me ctr6 Digestive gland 0.67 0.2 1.95 450 8.586 0.799 3.840 5.345 13.711 2.447 14.647 12.111 0.939 38.159 2.187 5.521 Mytilus edulis Control 0 15 15 27 Me ctr6 Digestive gland 0.67 0.1 2.00 450 8.586 0.409 16.188 9.127 25.896 6.642 27.264 22.922 1.605 48.407 4.029 3.681 Mytilus edulis Control 0 15 15 15 Me ctr8 Digestive gland 0.45 0.2 1.95 450 6.702 0.623 2.832 3.336 7.861 2.236 9.655 7.981 0.722 19.366 2.294 3.519 Mytilus edulis Control 0 15 15 27 Me ctr8 Digestive gland 0.45 0.1 2.00 450 6.702 0.319 11.089 6.336 13.187 5.468 19.909 14.446 0.828 28.575 3.554 2.137 Mytilus edulis Control 0 15 15 15 Me ctr10 Digestive gland 0.50 0.2 1.95 450 4.970 0.462 7.193 10.595 25.585 4.716 25.828 13.605 1.133 33.240 4.217 5.179 Mytilus edulis Control 0 15 15 27 Me ctr10 Digestive gland 0.50 0.1 2.00 450 4.970 0.237 20.831 10.684 21.482 8.493 40.930 30.512 2.520 53.014 15.006 2.424 Mytilus edulis Control 0 15 15 15 Me ctr11 Digestive gland 0.41 0.2 1.95 450 3.094 0.288 8.419 5.099 11.273 3.632 15.019 11.931 2.029 27.907 4.371 3.115 Mytilus edulis Control 0 15 15 27 Me ctr11 Digestive gland 0.41 0.1 2.00 450 3.094 0.147 20.971 11.296 23.435 8.478 26.203 16.579 2.971 39.710 16.386 2.605 Mytilus edulis Exposed 4 15 15 15 Me stat1 Digestive gland 0.51 0.2 1.95 450 3.094 0.288 5.784 6.832 17.643 4.859 21.489 17.776 1.894 50.283 8.193 4.054 Mytilus edulis Exposed 4 15 15 27 Me stat1 Digestive gland 0.51 0.1 2.00 450 3.094 0.147 9.133 12.702 41.074 10.057 52.072 39.442 3.036 84.568 10.214 3.977 Mytilus edulis Exposed 4 15 15 15 Me stat2 Digestive gland 0.47 0.2 1.95 450 7.814 0.727 2.504 3.594 9.326 1.841 10.682 8.628 0.842 19.532 3.077 4.716 Mytilus edulis Exposed 4 15 15 27 Me stat2 Digestive gland 0.47 0.1 2.00 450 7.814 0.372 9.491 4.498 7.493 3.856 18.095 15.598 1.135 28.198 6.453 1.721 Mytilus edulis Exposed 4 15 15 15 Me stat4 Digestive gland 0.62 0.2 1.95 450 9.789 0.911 3.284 4.883 13.220 2.264 14.010 10.443 0.805 22.758 1.846 5.815 Mytilus edulis Exposed 4 15 15 27 Me stat4 Digestive gland 0.62 0.1 2.00 450 9.789 0.466 4.274 6.418 17.332 4.981 25.922 18.405 0.416 32.127 2.202 3.334 Mytilus edulis Exposed 4 15 15 15 Me stat5 Digestive gland 0.43 0.2 1.95 450 6.343 0.590 3.963 4.359 10.002 2.771 11.189 9.791 0.882 20.488 1.687 3.990 Mytilus edulis Exposed 4 15 15 27 Me stat5 Digestive gland 0.43 0.1 2.00 450 6.343 0.302 11.571 7.171 15.536 6.082 20.945 16.284 1.834 28.062 4.162 2.274 Mytilus edulis Exposed 4 15 15 15 Me stat7 Digestive gland 0.45 0.2 1.95 450 5.644 0.525 4.402 5.843 14.015 2.528 15.627 9.607 0.803 26.684 4.604 5.501 Mytilus edulis Exposed 4 15 15 27 Me stat7 Digestive gland 0.45 0.1 2.00 450 5.644 0.269 5.791 7.977 24.254 5.836 30.563 19.391 0.638 41.023 4.219 4.162 Mytilus edulis Exposed 4 15 15 15 Me stat3 Digestive gland 0.46 0.2 1.95 450 5.644 0.525 2.382 3.505 7.395 2.798 9.467 8.954 1.345 18.263 2.703 2.563 Mytilus edulis Exposed 4 15 15 15 Me stat6 Digestive gland 0.36 0.2 1.95 450 6.702 0.623 3.533 3.570 7.719 2.324 9.352 7.930 1.634 12.287 2.219 3.214