Routti, Heli; Letcher, Robert J; Arukwe, Augustine; van Bavel, Bert; Yoccoz, Nigel G; Chu, Shaogang; Gabrielsen, Geir W (2008): (Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea [dataset]. PANGAEA, https://doi.org/10.1594/PANGAEA.819407, Supplement to: Routti, H et al. (2008): Biotransformation of PCBs in relation to phase I and II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environmental Science & Technology, 42(23), 8952-8958, https://doi.org/10.1021/es801682f
Always quote citation above when using data! You can download the citation in several formats below.
Abstract:
Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and <=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and <=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals.
Project(s):
Coverage:
Median Latitude: 72.033500 * Median Longitude: 21.171500 * South-bound Latitude: 65.167000 * West-bound Longitude: 18.010000 * North-bound Latitude: 78.900000 * East-bound Longitude: 24.333000
Event(s):
Comment:
Concentrations are given per gram wet weight.
Sum 43-PCB: CB-47/48,-52,-66,-74,-99/113,-101,-105,-110,-114/122,-118,-128,-138,-141,-153,-156,-157,-170/190,-172/192,-174,-177,-178,-180/193,-182/187,-183,-189,-194,-195,-196/203,-197,-199,-201/204,-202,-206,-209
Sum 4-OH-PCB: 4-0H-CB107, 4'-0H-CB108, 4-OH-CB163, 3'-OH-CB184
Sum 17-OH-PCB: 4-0H-CB107, 4'-0H-CB108, 3-OH-CB118, 4'-OH-CB120, 4-OH-CB134, 3'-OH-CB138, 4-OH-CB146, 4-OH-CB162, 4-OH-CB163, 4'-OH-CB172, 4'-OH-CB177, 4-OH-CB178, 4-OH-CB187, 4-OH-CB193, 4'-OH-CB199, 4'-OH-CB202, 4'-OH-CB208
Sum 10-MeSO2-PCB: 4-MeSO2-CB49, 4-MeSO2-CB64, 4-MeSO2-CB70, 4-MeSO2-CB87, 3-MeSO2-CB101, 4-MeSO2-CB101, 4-MeSO2-CB110, 4-MeSO2-CB132, 3-MeSO2-CB149, 4-MeSO2-CB174
Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150
Parameter(s):
| # | Name | Short Name | Unit | Principal Investigator | Method/Device | Comment |
|---|---|---|---|---|---|---|
| 1 | Event label | Event | ||||
| 2 | Sampling date | Sampling date | Routti, Heli | |||
| 3 | Area/locality | Area | Routti, Heli | |||
| 4 | Species, common name | Species common | Routti, Heli | |||
| 5 | Species | Species | Routti, Heli | |||
| 6 | Age, relative, number of years | Age | a | Routti, Heli | mean | |
| 7 | Age, standard deviation | Age std dev | ± | Routti, Heli | ||
| 8 | Age, relative, number of years | Age | a | Routti, Heli | min | |
| 9 | Age, relative, number of years | Age | a | Routti, Heli | max | |
| 10 | Male | Male | # | Routti, Heli | ||
| 11 | Female | Female | # | Routti, Heli | ||
| 12 | Sample type | Samp type | Routti, Heli | |||
| 13 | Lipids | Lipids | % | Routti, Heli | mean | |
| 14 | Lipids, standard deviation | Lipids std dev | ± | Routti, Heli | ||
| 15 | Lipids | Lipids | % | Routti, Heli | min | |
| 16 | Lipids | Lipids | % | Routti, Heli | max | |
| 17 | Sample amount, subset | N subset | # | Routti, Heli | lipids | |
| 18 | Polychlorinated biphenyl | PCB | µg/g | Routti, Heli | mean, sum 43 PCB | |
| 19 | Polychlorinated biphenyl, standard deviation | PCB std dev | ± | Routti, Heli | ||
| 20 | Polychlorinated biphenyl | PCB | µg/g | Routti, Heli | min, sum 43 PCB | |
| 21 | Polychlorinated biphenyl | PCB | µg/g | Routti, Heli | max, sum 43 PCB | |
| 22 | Sample amount, subset | N subset | # | Routti, Heli | sum 43 PCB | |
| 23 | Methyl sulfone polychlorinated biphenyl | MeSO2-PCB | ng/g | Routti, Heli | mean, sum 10 MeSO2-PCB | |
| 24 | Methyl sulfone polychlorinated biphenyl, standard deviation | MeSO2-PCB std dev | ± | Routti, Heli | ||
| 25 | Methyl sulfone polychlorinated biphenyl | MeSO2-PCB | ng/g | Routti, Heli | min, sum 10 MeSO2-PCB | |
| 26 | Methyl sulfone polychlorinated biphenyl | MeSO2-PCB | ng/g | Routti, Heli | max, sum 10 MeSO2-PCB | |
| 27 | Sample amount, subset | N subset | # | Routti, Heli | sum 10 MeSO2-PCB | |
| 28 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | mean, sum 4 OH-PCB | |
| 29 | Hydroxy-polychlorinated biphenyl, standard deviation | OH-PCB std dev | ± | Routti, Heli | sum 4 OH-PCB | |
| 30 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | min, sum 4 OH-PCB | |
| 31 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | max, sum 4 OH-PCB | |
| 32 | Sample amount, subset | N subset | # | Routti, Heli | sum 4 OH-PCB | |
| 33 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | mean, sum 17 OH-PCB | |
| 34 | Hydroxy-polychlorinated biphenyl, standard deviation | OH-PCB std dev | ± | Routti, Heli | sum 17 OH-PCB | |
| 35 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | min, sum 17 OH-PCB | |
| 36 | Hydroxy-polychlorinated biphenyl | OH-PCB | ng/g | Routti, Heli | max, sum 17 OH-PCB | |
| 37 | Sample amount, subset | N subset | # | Routti, Heli | sum 17 OH-PCB |
License:
Creative Commons Attribution 3.0 Unported (CC-BY-3.0)
Size:
102 data points