Not logged in
PANGAEA.
Data Publisher for Earth & Environmental Science

Routti, Heli; Letcher, Robert J; Arukwe, Augustine; van Bavel, Bert; Yoccoz, Nigel G; Chu, Shaogang; Gabrielsen, Geir W (2008): (Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea [dataset]. PANGAEA, https://doi.org/10.1594/PANGAEA.819407, Supplement to: Routti, H et al. (2008): Biotransformation of PCBs in relation to phase I and II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Environmental Science & Technology, 42(23), 8952-8958, https://doi.org/10.1021/es801682f

Always quote citation above when using data! You can download the citation in several formats below.

RIS CitationBibTeX CitationShow MapGoogle Earth

Abstract:
Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and <=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and <=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals.
Project(s):
International Polar Year (2007-2008) (IPY)
Coverage:
Median Latitude: 72.033500 * Median Longitude: 21.171500 * South-bound Latitude: 65.167000 * West-bound Longitude: 18.010000 * North-bound Latitude: 78.900000 * East-bound Longitude: 24.333000
Event(s):
BalticSea_Bothnia  * Latitude: 65.167000 * Longitude: 24.333000 * Location: Baltic Sea * Method/Device: Biological sample (BIOS)
Svalbard  * Latitude: 78.900000 * Longitude: 18.010000 * Location: Svalbard * Method/Device: Multiple investigations (MULT)
Comment:
Concentrations are given per gram wet weight.
Sum 43-PCB: CB-47/48,-52,-66,-74,-99/113,-101,-105,-110,-114/122,-118,-128,-138,-141,-153,-156,-157,-170/190,-172/192,-174,-177,-178,-180/193,-182/187,-183,-189,-194,-195,-196/203,-197,-199,-201/204,-202,-206,-209
Sum 4-OH-PCB: 4-0H-CB107, 4'-0H-CB108, 4-OH-CB163, 3'-OH-CB184
Sum 17-OH-PCB: 4-0H-CB107, 4'-0H-CB108, 3-OH-CB118, 4'-OH-CB120, 4-OH-CB134, 3'-OH-CB138, 4-OH-CB146, 4-OH-CB162, 4-OH-CB163, 4'-OH-CB172, 4'-OH-CB177, 4-OH-CB178, 4-OH-CB187, 4-OH-CB193, 4'-OH-CB199, 4'-OH-CB202, 4'-OH-CB208
Sum 10-MeSO2-PCB: 4-MeSO2-CB49, 4-MeSO2-CB64, 4-MeSO2-CB70, 4-MeSO2-CB87, 3-MeSO2-CB101, 4-MeSO2-CB101, 4-MeSO2-CB110, 4-MeSO2-CB132, 3-MeSO2-CB149, 4-MeSO2-CB174
Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150
Parameter(s):
#NameShort NameUnitPrincipal InvestigatorMethod/DeviceComment
1 Event labelEvent
2 Sampling dateSampling dateRoutti, Heli
3 Area/localityAreaRoutti, Heli
4 Species, common nameSpecies commonRoutti, Heli
5 SpeciesSpeciesRoutti, Heli
6 Age, relative, number of yearsAgeaRoutti, Helimean
7 Age, standard deviationAge std dev±Routti, Heli
8 Age, relative, number of yearsAgeaRoutti, Helimin
9 Age, relative, number of yearsAgeaRoutti, Helimax
10 MaleMale#Routti, Heli
11 FemaleFemale#Routti, Heli
12 Sample typeSamp typeRoutti, Heli
13 LipidsLipids%Routti, Helimean
14 Lipids, standard deviationLipids std dev±Routti, Heli
15 LipidsLipids%Routti, Helimin
16 LipidsLipids%Routti, Helimax
17 Sample amount, subsetN subset#Routti, Helilipids
18 Polychlorinated biphenylPCBµg/gRoutti, Helimean, sum 43 PCB
19 Polychlorinated biphenyl, standard deviationPCB std dev±Routti, Heli
20 Polychlorinated biphenylPCBµg/gRoutti, Helimin, sum 43 PCB
21 Polychlorinated biphenylPCBµg/gRoutti, Helimax, sum 43 PCB
22 Sample amount, subsetN subset#Routti, Helisum 43 PCB
23 Methyl sulfone polychlorinated biphenylMeSO2-PCBng/gRoutti, Helimean, sum 10 MeSO2-PCB
24 Methyl sulfone polychlorinated biphenyl, standard deviationMeSO2-PCB std dev±Routti, Heli
25 Methyl sulfone polychlorinated biphenylMeSO2-PCBng/gRoutti, Helimin, sum 10 MeSO2-PCB
26 Methyl sulfone polychlorinated biphenylMeSO2-PCBng/gRoutti, Helimax, sum 10 MeSO2-PCB
27 Sample amount, subsetN subset#Routti, Helisum 10 MeSO2-PCB
28 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimean, sum 4 OH-PCB
29 Hydroxy-polychlorinated biphenyl, standard deviationOH-PCB std dev±Routti, Helisum 4 OH-PCB
30 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimin, sum 4 OH-PCB
31 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimax, sum 4 OH-PCB
32 Sample amount, subsetN subset#Routti, Helisum 4 OH-PCB
33 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimean, sum 17 OH-PCB
34 Hydroxy-polychlorinated biphenyl, standard deviationOH-PCB std dev±Routti, Helisum 17 OH-PCB
35 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimin, sum 17 OH-PCB
36 Hydroxy-polychlorinated biphenylOH-PCBng/gRoutti, Helimax, sum 17 OH-PCB
37 Sample amount, subsetN subset#Routti, Helisum 17 OH-PCB
License:
Creative Commons Attribution 3.0 Unported (CC-BY-3.0)
Size:
102 data points

Data

Download dataset as tab-delimited text — use the following character encoding:

1 
Event		2 
Sampling date		3 
Area		4 
Species common		5 
Species		6 
Age [a]
(mean)		7 
Age std dev [±]		8 
Age [a]
(min)		9 
Age [a]
(max)		10 
Male [#]		11 
Female [#]		12 
Samp type		13 
Lipids [%]
(mean)		14 
Lipids std dev [±]		15 
Lipids [%]
(min)		16 
Lipids [%]
(max)		17 
N subset [#]
(lipids)		18 
PCB [µg/g]
(mean, sum 43 PCB)		19 
PCB std dev [±]		20 
PCB [µg/g]
(min, sum 43 PCB)		21 
PCB [µg/g]
(max, sum 43 PCB)		22 
N subset [#]
(sum 43 PCB)		23 
MeSO2-PCB [ng/g]
(mean, sum 10 MeSO2-PCB)		24 
MeSO2-PCB std dev [±]		25 
MeSO2-PCB [ng/g]
(min, sum 10 MeSO2-PCB)		26 
MeSO2-PCB [ng/g]
(max, sum 10 MeSO2-PCB)		27 
N subset [#]
(sum 10 MeSO2-PCB)		28 
OH-PCB [ng/g]
(mean, sum 4 OH-PCB)		29 
OH-PCB std dev [±]
(sum 4 OH-PCB)		30 
OH-PCB [ng/g]
(min, sum 4 OH-PCB)		31 
OH-PCB [ng/g]
(max, sum 4 OH-PCB)		32 
N subset [#]
(sum 4 OH-PCB)		33 
OH-PCB [ng/g]
(mean, sum 17 OH-PCB)		34 
OH-PCB std dev [±]
(sum 17 OH-PCB)		35 
OH-PCB [ng/g]
(min, sum 17 OH-PCB)		36 
OH-PCB [ng/g]
(max, sum 17 OH-PCB)		37 
N subset [#]
(sum 17 OH-PCB)
Svalbard May/June 2007SvalbardRinged sealPhoca hispida10.61.60231147liver3.300.112.804.9210.0450.00940.00900.13018<0.34.821
SvalbardMay/June 2007SvalbardRinged sealPhoca hispida10.61.60231147plasma0.700.040.421.1180.0220.01400.00260.260180.370.06<0.021.219
BalticSea_Bothnia April 2002/2006/2007BalticRinged sealPhoca hispida9.20.932201913liver3.800.132.605.6310.8630.20200.14106.47231223.9<0.396.027
BalticSea_BothniaApril 2002/2006/2007BalticRinged sealPhoca hispida9.20.932201913plasma0.670.030.241.0300.0570.00870.00460.1853013.81.53.13730