Citation:

es903029j

Name: (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard
Published: 2010
License: https://creativecommons.org/licenses/by/3.0/

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Published: 2010 (exact date unknown) • DOI registered: 2013-05-16

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Abstract:

Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on TTR for T4 in wild living polar bears are completely saturated. Such saturation of binding sites can explain observed lowered levels of THs and could lead to contaminant transport into the developing fetus.

Project(s):

International Polar Year (2007-2008) (IPY)

Coverage:

Latitude: 78.900000 * Longitude: 18.010000

Event(s):

Svalbard_bear * Latitude: 78.900000 * Longitude: 18.010000 * Location: Svalbard * Method/Device: Biological sample (BIOS)

Comment:

Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150

Parameter(s):

#	Name	Short Name	Unit	Principal Investigator	Comment
1	Ursus maritimus	U. maritimus	#	Gutleb, Arno C
2	Sex	Sex		Gutleb, Arno C
3	Age, relative, number of years	Age	a	Gutleb, Arno C	mean
4	Age, comment	Comm		Gutleb, Arno C	individual ages; M = male, F = female
5	Polychlorinated biphenyl 47	PCB_47	µg/g	Gutleb, Arno C	mean
6	Polychlorinated biphenyl 47	PCB_47	µg/g	Gutleb, Arno C	min
7	Polychlorinated biphenyl 47	PCB_47	µg/g	Gutleb, Arno C	max
8	Polychlorinated biphenyl 99	PCB_99	µg/g	Gutleb, Arno C	mean
9	Polychlorinated biphenyl 99	PCB_99	µg/g	Gutleb, Arno C	min
10	Polychlorinated biphenyl 99	PCB_99	µg/g	Gutleb, Arno C	max
11	Polychlorinated biphenyl 118	PCB_118	µg/g	Gutleb, Arno C	mean
12	Polychlorinated biphenyl 118	PCB_118	µg/g	Gutleb, Arno C	min
13	Polychlorinated biphenyl 118	PCB_118	µg/g	Gutleb, Arno C	max
14	Polychlorinated biphenyl 128	PCB_128	µg/g	Gutleb, Arno C	mean
15	Polychlorinated biphenyl 128	PCB_128	µg/g	Gutleb, Arno C	min
16	Polychlorinated biphenyl 128	PCB_128	µg/g	Gutleb, Arno C	max
17	Polychlorinated biphenyl 137	PCB_137	µg/g	Gutleb, Arno C	mean
18	Polychlorinated biphenyl 137	PCB_137	µg/g	Gutleb, Arno C	min
19	Polychlorinated biphenyl 137	PCB_137	µg/g	Gutleb, Arno C	max
20	Polychlorinated biphenyl 138	PCB_138	µg/g	Gutleb, Arno C	mean
21	Polychlorinated biphenyl 138	PCB_138	µg/g	Gutleb, Arno C	min
22	Polychlorinated biphenyl 138	PCB_138	µg/g	Gutleb, Arno C	max
23	Polychlorinated biphenyl 153	PCB_153	µg/g	Gutleb, Arno C	mean
24	Polychlorinated biphenyl 153	PCB_153	µg/g	Gutleb, Arno C	min
25	Polychlorinated biphenyl 153	PCB_153	µg/g	Gutleb, Arno C	max
26	Polychlorinated biphenyl 156	PCB_156	µg/g	Gutleb, Arno C	mean
27	Polychlorinated biphenyl 156	PCB_156	µg/g	Gutleb, Arno C	min
28	Polychlorinated biphenyl 156	PCB_156	µg/g	Gutleb, Arno C	max
29	Polychlorinated biphenyl 157	PCB_157	µg/g	Gutleb, Arno C	mean
30	Polychlorinated biphenyl 157	PCB_157	µg/g	Gutleb, Arno C	min
31	Polychlorinated biphenyl 157	PCB_157	µg/g	Gutleb, Arno C	max
32	Polychlorinated biphenyl 170	PCB_170	µg/g	Gutleb, Arno C	mean
33	Polychlorinated biphenyl 170	PCB_170	µg/g	Gutleb, Arno C	min
34	Polychlorinated biphenyl 170	PCB_170	µg/g	Gutleb, Arno C	max
35	Polychlorinated biphenyl 180	PCB_180	µg/g	Gutleb, Arno C	mean
36	Polychlorinated biphenyl 180	PCB_180	µg/g	Gutleb, Arno C	min
37	Polychlorinated biphenyl 180	PCB_180	µg/g	Gutleb, Arno C	max
38	Polychlorinated biphenyl 183	PCB_183	µg/g	Gutleb, Arno C	mean
39	Polychlorinated biphenyl 183	PCB_183	µg/g	Gutleb, Arno C	min
40	Polychlorinated biphenyl 183	PCB_183	µg/g	Gutleb, Arno C	max
41	Polychlorinated biphenyl 187	PCB_187	µg/g	Gutleb, Arno C	mean
42	Polychlorinated biphenyl 187	PCB_187	µg/g	Gutleb, Arno C	min
43	Polychlorinated biphenyl 187	PCB_187	µg/g	Gutleb, Arno C	max
44	Polychlorinated biphenyl 189	PCB_189	µg/g	Gutleb, Arno C	mean
45	Polychlorinated biphenyl 189	PCB_189	µg/g	Gutleb, Arno C	min
46	Polychlorinated biphenyl 189	PCB_189	µg/g	Gutleb, Arno C	max
47	Polychlorinated biphenyl 194	PCB_194	µg/g	Gutleb, Arno C	mean
48	Polychlorinated biphenyl 194	PCB_194	µg/g	Gutleb, Arno C	min
49	Polychlorinated biphenyl 194	PCB_194	µg/g	Gutleb, Arno C	max
50	Polychlorinated biphenyl 206	PCB_206	µg/g	Gutleb, Arno C	mean
51	Polychlorinated biphenyl 206	PCB_206	µg/g	Gutleb, Arno C	min
52	Polychlorinated biphenyl 206	PCB_206	µg/g	Gutleb, Arno C	max
53	Hydroxy-polychlorinated biphenyl 107	OH-PCB_107	ng/g	Gutleb, Arno C	mean
54	Hydroxy-polychlorinated biphenyl 107	OH-PCB_107	ng/g	Gutleb, Arno C	min
55	Hydroxy-polychlorinated biphenyl 107	OH-PCB_107	ng/g	Gutleb, Arno C	max
56	Hydroxy-polychlorinated biphenyl 146	OH-PCB_146	ng/g	Gutleb, Arno C	mean
57	Hydroxy-polychlorinated biphenyl 146	OH-PCB_146	ng/g	Gutleb, Arno C	min
58	Hydroxy-polychlorinated biphenyl 146	OH-PCB_146	ng/g	Gutleb, Arno C	max
59	Hydroxy-polychlorinated biphenyl 187	OH-PCB_187	ng/g	Gutleb, Arno C	mean
60	Hydroxy-polychlorinated biphenyl 187	OH-PCB_187	ng/g	Gutleb, Arno C	min
61	Hydroxy-polychlorinated biphenyl 187	OH-PCB_187	ng/g	Gutleb, Arno C	max
62	Hydroxylated polybrominated diphenyl ethers	OH-PBDE	ng/g	Gutleb, Arno C	mean, congener BDE-47
63	2,4,6-Tribromophenol	TBP	ng/g	Gutleb, Arno C	mean
64	para,para-Dichlorodiphenyldichloroethylene	pp-DDE	µg/kg	Gutleb, Arno C	mean
65	para,para-Dichlorodiphenyldichloroethylene	pp-DDE	µg/kg	Gutleb, Arno C	min
66	para,para-Dichlorodiphenyldichloroethylene	pp-DDE	µg/kg	Gutleb, Arno C	max
67	Pentachlorophenol	PCP	ng/g	Gutleb, Arno C	mean
68	Hexachlorobenzene	HCB	µg/g	Gutleb, Arno C	mean
69	Hexachlorobenzene	HCB	µg/g	Gutleb, Arno C	min
70	Hexachlorobenzene	HCB	µg/g	Gutleb, Arno C	max
71	alpha-Hexachlorocyclohexane	a-HCH	µg/kg	Gutleb, Arno C	mean
72	alpha-Hexachlorocyclohexane	a-HCH	µg/kg	Gutleb, Arno C	min
73	alpha-Hexachlorocyclohexane	a-HCH	µg/kg	Gutleb, Arno C	max
74	beta-Hexachlorocyclohexane	b-HCH	µg/kg	Gutleb, Arno C	mean
75	beta-Hexachlorocyclohexane	b-HCH	µg/kg	Gutleb, Arno C	min
76	beta-Hexachlorocyclohexane	b-HCH	µg/kg	Gutleb, Arno C	max
77	Oxychlordane	oxy-CHL	µg/g	Gutleb, Arno C	mean
78	Oxychlordane	oxy-CHL	µg/g	Gutleb, Arno C	min
79	Oxychlordane	oxy-CHL	µg/g	Gutleb, Arno C	max
80	trans-Nonachlor	trans-Nonachlor	µg/g	Gutleb, Arno C	mean
81	trans-Nonachlor	trans-Nonachlor	µg/g	Gutleb, Arno C	min
82	trans-Nonachlor	trans-Nonachlor	µg/g	Gutleb, Arno C	max

License:

Creative Commons Attribution 3.0 Unported (CC-BY-3.0)

Size:

82 data points

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