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Gutleb, Arno C; Cenijn, Peter; van Velzen, Martin; Lie, Elisabeth; Ropstad, Erik; Skaare, Janneche Utne; Malmberg, Tina; Bergman, Åke; Gabrielsen, Geir W; Legler, Juliette (2010): (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard. PANGAEA,, Supplement to: Gutleb, AC et al. (2010): In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). Environmental Science & Technology, 44(8), 3149-3154,

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Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on TTR for T4 in wild living polar bears are completely saturated. Such saturation of binding sites can explain observed lowered levels of THs and could lead to contaminant transport into the developing fetus.
Latitude: 78.900000 * Longitude: 18.010000
Svalbard_bear * Latitude: 78.900000 * Longitude: 18.010000 * Location: Svalbard * Method/Device: Biological sample (BIOS)
Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see
#NameShort NameUnitPrincipal InvestigatorMethod/DeviceComment
1Ursus maritimusU. maritimus#Gutleb, Arno C
2SexSexGutleb, Arno C
3Age, relative, number of yearsAgeaGutleb, Arno Cmean
4Age, commentCommGutleb, Arno Cindividual ages; M = male, F = female
5Polychlorinated biphenyl 47PCB_47µg/gGutleb, Arno Cmean
6Polychlorinated biphenyl 47PCB_47µg/gGutleb, Arno Cmin
7Polychlorinated biphenyl 47PCB_47µg/gGutleb, Arno Cmax
8Polychlorinated biphenyl 99PCB_99µg/gGutleb, Arno Cmean
9Polychlorinated biphenyl 99PCB_99µg/gGutleb, Arno Cmin
10Polychlorinated biphenyl 99PCB_99µg/gGutleb, Arno Cmax
11Polychlorinated biphenyl 118PCB_118µg/gGutleb, Arno Cmean
12Polychlorinated biphenyl 118PCB_118µg/gGutleb, Arno Cmin
13Polychlorinated biphenyl 118PCB_118µg/gGutleb, Arno Cmax
14Polychlorinated biphenyl 128PCB_128µg/gGutleb, Arno Cmean
15Polychlorinated biphenyl 128PCB_128µg/gGutleb, Arno Cmin
16Polychlorinated biphenyl 128PCB_128µg/gGutleb, Arno Cmax
17Polychlorinated biphenyl 137PCB_137µg/gGutleb, Arno Cmean
18Polychlorinated biphenyl 137PCB_137µg/gGutleb, Arno Cmin
19Polychlorinated biphenyl 137PCB_137µg/gGutleb, Arno Cmax
20Polychlorinated biphenyl 138PCB_138µg/gGutleb, Arno Cmean
21Polychlorinated biphenyl 138PCB_138µg/gGutleb, Arno Cmin
22Polychlorinated biphenyl 138PCB_138µg/gGutleb, Arno Cmax
23Polychlorinated biphenyl 153PCB_153µg/gGutleb, Arno Cmean
24Polychlorinated biphenyl 153PCB_153µg/gGutleb, Arno Cmin
25Polychlorinated biphenyl 153PCB_153µg/gGutleb, Arno Cmax
26Polychlorinated biphenyl 156PCB_156µg/gGutleb, Arno Cmean
27Polychlorinated biphenyl 156PCB_156µg/gGutleb, Arno Cmin
28Polychlorinated biphenyl 156PCB_156µg/gGutleb, Arno Cmax
29Polychlorinated biphenyl 157PCB_157µg/gGutleb, Arno Cmean
30Polychlorinated biphenyl 157PCB_157µg/gGutleb, Arno Cmin
31Polychlorinated biphenyl 157PCB_157µg/gGutleb, Arno Cmax
32Polychlorinated biphenyl 170PCB_170µg/gGutleb, Arno Cmean
33Polychlorinated biphenyl 170PCB_170µg/gGutleb, Arno Cmin
34Polychlorinated biphenyl 170PCB_170µg/gGutleb, Arno Cmax
35Polychlorinated biphenyl 180PCB_180µg/gGutleb, Arno Cmean
36Polychlorinated biphenyl 180PCB_180µg/gGutleb, Arno Cmin
37Polychlorinated biphenyl 180PCB_180µg/gGutleb, Arno Cmax
38Polychlorinated biphenyl 183PCB_183µg/gGutleb, Arno Cmean
39Polychlorinated biphenyl 183PCB_183µg/gGutleb, Arno Cmin
40Polychlorinated biphenyl 183PCB_183µg/gGutleb, Arno Cmax
41Polychlorinated biphenyl 187PCB_187µg/gGutleb, Arno Cmean
42Polychlorinated biphenyl 187PCB_187µg/gGutleb, Arno Cmin
43Polychlorinated biphenyl 187PCB_187µg/gGutleb, Arno Cmax
44Polychlorinated biphenyl 189PCB_189µg/gGutleb, Arno Cmean
45Polychlorinated biphenyl 189PCB_189µg/gGutleb, Arno Cmin
46Polychlorinated biphenyl 189PCB_189µg/gGutleb, Arno Cmax
47Polychlorinated biphenyl 194PCB_194µg/gGutleb, Arno Cmean
48Polychlorinated biphenyl 194PCB_194µg/gGutleb, Arno Cmin
49Polychlorinated biphenyl 194PCB_194µg/gGutleb, Arno Cmax
50Polychlorinated biphenyl 206PCB_206µg/gGutleb, Arno Cmean
51Polychlorinated biphenyl 206PCB_206µg/gGutleb, Arno Cmin
52Polychlorinated biphenyl 206PCB_206µg/gGutleb, Arno Cmax
53Hydroxy-polychlorinated biphenyl 107OH-PCB_107ng/gGutleb, Arno Cmean
54Hydroxy-polychlorinated biphenyl 107OH-PCB_107ng/gGutleb, Arno Cmin
55Hydroxy-polychlorinated biphenyl 107OH-PCB_107ng/gGutleb, Arno Cmax
56Hydroxy-polychlorinated biphenyl 146OH-PCB_146ng/gGutleb, Arno Cmean
57Hydroxy-polychlorinated biphenyl 146OH-PCB_146ng/gGutleb, Arno Cmin
58Hydroxy-polychlorinated biphenyl 146OH-PCB_146ng/gGutleb, Arno Cmax
59Hydroxy-polychlorinated biphenyl 187OH-PCB_187ng/gGutleb, Arno Cmean
60Hydroxy-polychlorinated biphenyl 187OH-PCB_187ng/gGutleb, Arno Cmin
61Hydroxy-polychlorinated biphenyl 187OH-PCB_187ng/gGutleb, Arno Cmax
62Hydroxylated polybrominated diphenyl ethersOH-PBDEng/gGutleb, Arno Cmean, congener BDE-47
632,4,6-TribromophenolTBPng/gGutleb, Arno Cmean
64para,para-Dichlorodiphenyldichloroethylenepp-DDEµg/kgGutleb, Arno Cmean
65para,para-Dichlorodiphenyldichloroethylenepp-DDEµg/kgGutleb, Arno Cmin
66para,para-Dichlorodiphenyldichloroethylenepp-DDEµg/kgGutleb, Arno Cmax
67PentachlorophenolPCPng/gGutleb, Arno Cmean
68HexachlorobenzeneHCBµg/gGutleb, Arno Cmean
69HexachlorobenzeneHCBµg/gGutleb, Arno Cmin
70HexachlorobenzeneHCBµg/gGutleb, Arno Cmax
71alpha-Hexachlorocyclohexanea-HCHµg/kgGutleb, Arno Cmean
72alpha-Hexachlorocyclohexanea-HCHµg/kgGutleb, Arno Cmin
73alpha-Hexachlorocyclohexanea-HCHµg/kgGutleb, Arno Cmax
74beta-Hexachlorocyclohexaneb-HCHµg/kgGutleb, Arno Cmean
75beta-Hexachlorocyclohexaneb-HCHµg/kgGutleb, Arno Cmin
76beta-Hexachlorocyclohexaneb-HCHµg/kgGutleb, Arno Cmax
77Oxychlordaneoxy-CHLµg/gGutleb, Arno Cmean
78Oxychlordaneoxy-CHLµg/gGutleb, Arno Cmin
79Oxychlordaneoxy-CHLµg/gGutleb, Arno Cmax
80trans-Nonachlort-Nonachlorµg/gGutleb, Arno Cmean
81trans-Nonachlort-Nonachlorµg/gGutleb, Arno Cmin
82trans-Nonachlort-Nonachlorµg/gGutleb, Arno Cmax
82 data points

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