/* DATA DESCRIPTION: Citation: Gutleb, Arno C; Cenijn, Peter; van Velzen, Martin; Lie, Elisabeth; Ropstad, Erik; Skaare, Janneche Utne; Malmberg, Tina; Bergman, Åke; Gabrielsen, Geir W; Legler, Juliette (2010): (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard. PANGAEA, https://doi.org/10.1594/PANGAEA.810387, Supplement to: Gutleb, AC et al. (2010): In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). Environmental Science & Technology, 44(8), 3149-3154, https://doi.org/10.1021/es903029j Abstract: Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on TTR for T4 in wild living polar bears are completely saturated. Such saturation of binding sites can explain observed lowered levels of THs and could lead to contaminant transport into the developing fetus. Project(s): International Polar Year (2007-2008) (IPY) (URI: https://www.ipy.org/) Coverage: LATITUDE: 78.900000 * LONGITUDE: 18.010000 Event(s): Svalbard_bear * LATITUDE: 78.900000 * LONGITUDE: 18.010000 * LOCATION: Svalbard * METHOD/DEVICE: Biological sample (BIOS) Comment: Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 Parameter(s): Ursus maritimus [#] (U. maritimus) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) Sex (Sex) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) Age, relative, number of years [a] (Age) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Age, comment (Comm) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: individual ages; M = male, F = female Polychlorinated biphenyl 47 [µg/g] (PCB_47) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 47 [µg/g] (PCB_47) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 47 [µg/g] (PCB_47) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 99 [µg/g] (PCB_99) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 99 [µg/g] (PCB_99) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 99 [µg/g] (PCB_99) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 118 [µg/g] (PCB_118) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 118 [µg/g] (PCB_118) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 118 [µg/g] (PCB_118) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 128 [µg/g] (PCB_128) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 128 [µg/g] (PCB_128) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 128 [µg/g] (PCB_128) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 137 [µg/g] (PCB_137) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 137 [µg/g] (PCB_137) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 137 [µg/g] (PCB_137) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 138 [µg/g] (PCB_138) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 138 [µg/g] (PCB_138) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 138 [µg/g] (PCB_138) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 153 [µg/g] (PCB_153) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 153 [µg/g] (PCB_153) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 153 [µg/g] (PCB_153) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 156 [µg/g] (PCB_156) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 156 [µg/g] (PCB_156) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 156 [µg/g] (PCB_156) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 157 [µg/g] (PCB_157) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 157 [µg/g] (PCB_157) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 157 [µg/g] (PCB_157) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 170 [µg/g] (PCB_170) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 170 [µg/g] (PCB_170) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 170 [µg/g] (PCB_170) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 180 [µg/g] (PCB_180) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 180 [µg/g] (PCB_180) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 180 [µg/g] (PCB_180) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 183 [µg/g] (PCB_183) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 183 [µg/g] (PCB_183) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 183 [µg/g] (PCB_183) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 187 [µg/g] (PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 187 [µg/g] (PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 187 [µg/g] (PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 189 [µg/g] (PCB_189) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 189 [µg/g] (PCB_189) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 189 [µg/g] (PCB_189) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 194 [µg/g] (PCB_194) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 194 [µg/g] (PCB_194) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 194 [µg/g] (PCB_194) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Polychlorinated biphenyl 206 [µg/g] (PCB_206) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Polychlorinated biphenyl 206 [µg/g] (PCB_206) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Polychlorinated biphenyl 206 [µg/g] (PCB_206) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Hydroxy-polychlorinated biphenyl 107 [ng/g] (OH-PCB_107) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Hydroxy-polychlorinated biphenyl 107 [ng/g] (OH-PCB_107) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Hydroxy-polychlorinated biphenyl 107 [ng/g] (OH-PCB_107) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Hydroxy-polychlorinated biphenyl 146 [ng/g] (OH-PCB_146) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Hydroxy-polychlorinated biphenyl 146 [ng/g] (OH-PCB_146) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Hydroxy-polychlorinated biphenyl 146 [ng/g] (OH-PCB_146) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Hydroxy-polychlorinated biphenyl 187 [ng/g] (OH-PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Hydroxy-polychlorinated biphenyl 187 [ng/g] (OH-PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Hydroxy-polychlorinated biphenyl 187 [ng/g] (OH-PCB_187) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Hydroxylated polybrominated diphenyl ethers [ng/g] (OH-PBDE) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean, congener BDE-47 2,4,6-Tribromophenol [ng/g] (TBP) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean para,para-Dichlorodiphenyldichloroethylene [µg/kg] (pp-DDE) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean para,para-Dichlorodiphenyldichloroethylene [µg/kg] (pp-DDE) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min para,para-Dichlorodiphenyldichloroethylene [µg/kg] (pp-DDE) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Pentachlorophenol [ng/g] (PCP) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Hexachlorobenzene [µg/g] (HCB) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Hexachlorobenzene [µg/g] (HCB) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Hexachlorobenzene [µg/g] (HCB) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max alpha-Hexachlorocyclohexane [µg/kg] (a-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean alpha-Hexachlorocyclohexane [µg/kg] (a-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min alpha-Hexachlorocyclohexane [µg/kg] (a-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max beta-Hexachlorocyclohexane [µg/kg] (b-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean beta-Hexachlorocyclohexane [µg/kg] (b-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min beta-Hexachlorocyclohexane [µg/kg] (b-HCH) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max Oxychlordane [µg/g] (oxy-CHL) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean Oxychlordane [µg/g] (oxy-CHL) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min Oxychlordane [µg/g] (oxy-CHL) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max trans-Nonachlor [µg/g] (t-Nonachlor) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: mean trans-Nonachlor [µg/g] (t-Nonachlor) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: min trans-Nonachlor [µg/g] (t-Nonachlor) * PI: Gutleb, Arno C (https://orcid.org/0000-0001-9725-9112, gutleb@lippmann.lu) * COMMENT: max License: Creative Commons Attribution 3.0 Unported (CC-BY-3.0) (URI: https://creativecommons.org/licenses/by/3.0/) Size: 82 data points */ U. maritimus [#] Sex Age [a] (mean) Comm (individual ages; M = male, F ...) PCB_47 [µg/g] (mean) PCB_47 [µg/g] (min) PCB_47 [µg/g] (max) PCB_99 [µg/g] (mean) PCB_99 [µg/g] (min) PCB_99 [µg/g] (max) PCB_118 [µg/g] (mean) PCB_118 [µg/g] (min) PCB_118 [µg/g] (max) PCB_128 [µg/g] (mean) PCB_128 [µg/g] (min) PCB_128 [µg/g] (max) PCB_137 [µg/g] (mean) PCB_137 [µg/g] (min) PCB_137 [µg/g] (max) PCB_138 [µg/g] (mean) PCB_138 [µg/g] (min) PCB_138 [µg/g] (max) PCB_153 [µg/g] (mean) PCB_153 [µg/g] (min) PCB_153 [µg/g] (max) PCB_156 [µg/g] (mean) PCB_156 [µg/g] (min) PCB_156 [µg/g] (max) PCB_157 [µg/g] (mean) PCB_157 [µg/g] (min) PCB_157 [µg/g] (max) PCB_170 [µg/g] (mean) PCB_170 [µg/g] (min) PCB_170 [µg/g] (max) PCB_180 [µg/g] (mean) PCB_180 [µg/g] (min) PCB_180 [µg/g] (max) PCB_183 [µg/g] (mean) PCB_183 [µg/g] (min) PCB_183 [µg/g] (max) PCB_187 [µg/g] (mean) PCB_187 [µg/g] (min) PCB_187 [µg/g] (max) PCB_189 [µg/g] (mean) PCB_189 [µg/g] (min) PCB_189 [µg/g] (max) PCB_194 [µg/g] (mean) PCB_194 [µg/g] (min) PCB_194 [µg/g] (max) PCB_206 [µg/g] (mean) PCB_206 [µg/g] (min) PCB_206 [µg/g] (max) OH-PCB_107 [ng/g] (mean) OH-PCB_107 [ng/g] (min) OH-PCB_107 [ng/g] (max) OH-PCB_146 [ng/g] (mean) OH-PCB_146 [ng/g] (min) OH-PCB_146 [ng/g] (max) OH-PCB_187 [ng/g] (mean) OH-PCB_187 [ng/g] (min) OH-PCB_187 [ng/g] (max) OH-PBDE [ng/g] (mean, congener BDE-47) TBP [ng/g] (mean) pp-DDE [µg/kg] (mean) pp-DDE [µg/kg] (min) pp-DDE [µg/kg] (max) PCP [ng/g] (mean) HCB [µg/g] (mean) HCB [µg/g] (min) HCB [µg/g] (max) a-HCH [µg/kg] (mean) a-HCH [µg/kg] (min) a-HCH [µg/kg] (max) b-HCH [µg/kg] (mean) b-HCH [µg/kg] (min) b-HCH [µg/kg] (max) oxy-CHL [µg/g] (mean) oxy-CHL [µg/g] (min) oxy-CHL [µg/g] (max) t-Nonachlor [µg/g] (mean) t-Nonachlor [µg/g] (min) t-Nonachlor [µg/g] (max) 6 3 male, 3 female 11 M:6,17,21; F:7,7,8 0.0005 0.0002 0.0012 0.0134 0.0039 0.0293 0.0002 0.0002 0.0003 0.0003 0 0.0006 0.0009 0.0002 0.002 0.0129 0.0038 0.0286 0.0573 0.0196 0.125 0.0017 0.0009 0.0036 0.0016 0.0007 0.003 0.0159 0.0055 0.0293 0.0399 0.0159 0.081 0.0008 0.0001 0.0017 0.0001 0 0.0002 0.0004 0.0002 0.0007 0.0077 0.0027 0.015 0.0012 0.0008 0.0025 13.6 9.9 16 166 46.7 252 68.7 14.1 111.3 <0.05 <1.45 2.1 0.8 6.7 <1.35 0.0023 0.0003 0.0055 0.3 0.3 0.4 1.1 0.9 1.9 0.0259 0.0011 0.0556 0.0019 0.0003 0.0041