Citation:

PANGAEA.963943

Name: Distribution of pharmaceutical compounds in coastal waters of the North Sea in March 2023
Published: 2023-12-15
License: https://creativecommons.org/licenses/by/4.0/
Keywords: Jade Bay; Marine environments; North Sea; Pharmaceutical compounds; sea surface microlayer; Spatial and vertical distributions; wastewater

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Published: 2023-12-15 • DOI registered: 2024-01-13

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Abstract:

We investigated the occurrence, spatial, and vertical distributions of 63 pharmaceutical compounds and six artificial sweeteners from the sea surface microlayer (SML) to five different depths (0 cm, 20 cm, 50 cm, 100 cm, and 150 cm) of the corresponding underlying waters in four stations of the North Sea. One station is a coastal area (Jade Bay), one station is an estuary (Bremerhaven), and the other two stations (NS_7 and NS_8) are open coastal waters. We will refer to each environment with the name in brackets throughout this publication. We collected seawater samples vertically from these stations and analyzed them using ultra-performance liquid chromatography - triple quadrupole mass spectrometry in tandem with ionization spray (UPLC-QqQMS/MS) (Bruker EVOQ Elite system Bruker, USA) at the Department of Physical Chemistry, University of Cádiz.

Keyword(s):

Jade Bay; Marine environments; North Sea; Pharmaceutical compounds; sea surface microlayer; Spatial and vertical distributions; wastewater

Supplement to:

Adenaya, Adenike; Rios Quintero, Ruben; Brinkhoff, Thorsten; Lara-Martín, Pablo A; Wurl, Oliver; Ribas-Ribas, Mariana (2023): Vertical Distribution of Pharmaceutical Contaminants in North Sea Coastal Waters and Risk Assessments. Preprint, SSRN, https://doi.org/10.2139/ssrn.4623663

Further details:

Adenaya, Adenike (2023): Supplementary information for distribution of pharmaceutical compounds in coastal waters of the North Sea. Supplementary_data_Vertical_Distribution_of_Pharmaceutical_Compounds.pdf

Coverage:

Median Latitude: 53.907693 * Median Longitude: 7.940682 * South-bound Latitude: 53.523002 * West-bound Longitude: 7.245698 * North-bound Latitude: 54.868190 * East-bound Longitude: 8.580609

Date/Time Start: 2023-03-12T07:12:00 * Date/Time End: 2023-03-19T08:16:00

Minimum DEPTH, water: 0.0 m * Maximum DEPTH, water: 1.5 m

Event(s):

HE614_20-2 * Latitude Start: 53.533743 * Longitude Start: 8.183051 * Latitude End: 53.599136 * Longitude End: 8.162742 * Date/Time Start: 2023-03-12T07:03:50 * Date/Time End: 2023-03-12T08:00:01 * Elevation Start: -26.0 m * Elevation End: -17.0 m * Location: North Sea * Campaign: (SCANS) * Basis: * Method/Device: Rubber boat, Zodiac (ZODIAC)

HE614_21-1 * Latitude Start: 53.523010 * Longitude Start: 8.580611 * Latitude End: 53.523003 * Longitude End: 8.580611 * Date/Time Start: 2023-03-13T07:00:01 * Date/Time End: 2023-03-13T13:30:59 * Location: North Sea * Campaign: (SCANS) * Basis: * Method/Device: CATAMARAN (CATM)

HE614_28-6 * Latitude Start: 53.853523 * Longitude Start: 7.565429 * Latitude End: 53.865614 * Longitude End: 7.631295 * Date/Time Start: 2023-03-17T12:59:35 * Date/Time End: 2023-03-17T15:24:31 * Elevation Start: -18.0 m * Elevation End: -19.0 m * Location: North Sea * Campaign: (SCANS) * Basis: * Method/Device: Rubber boat, Zodiac (ZODIAC)

Comment:

The value <0.001 in the data table refers to 'below the detection limit'. The specific limit of quantification for each pharmaceutical compound can be found in the supplementary information.

Parameter(s):

#	Name	Short Name	Unit	Principal Investigator	Method/Device	Comment
1	Event label	Event		Adenaya, Adenike
2	LATITUDE	Latitude		Adenaya, Adenike		Geocode
3	LONGITUDE	Longitude		Adenaya, Adenike		Geocode
4	DATE/TIME	Date/Time		Adenaya, Adenike		Geocode
5	Salinity	Sal		Adenaya, Adenike	Thermosalinograph (TSG)
6	Temperature, water	Temp	°C	Adenaya, Adenike	Thermosalinograph (TSG)
7	Wind speed	ff	m/s	Adenaya, Adenike	Ship Weather Station (SWEAS)
8	DEPTH, water	Depth water	m	Adenaya, Adenike		Geocode
9	Station label	Station		Adenaya, Adenike
10	Device type	Device		Adenaya, Adenike
11	Sample type	Samp type		Adenaya, Adenike
12	Acetaminophen	Acetaminophen	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
13	Diclofenac	Diclofenac	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
14	Fenoprofen	Fenoprofen	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
15	Ibuprofen	Ibuprofen	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
16	Indometacin	Indometacin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
17	Ketoprofen	Ketoprofen	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
18	Mefenamic acid	Mefenamic acid	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
19	Naproxen	Naproxen	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
20	Phenylbutazone	Phenylbutazone	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
21	Acetylsalicylic acid	Acetylsalicylic acid	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-inflammatory
22	Atenolol	Atenolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
23	Pindolol	Pindolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
24	Nadolol	Nadolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
25	Metoprolol	Metoprolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
26	Timolol	Timolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
27	Propanolol	Propanolol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Beta-blocker
28	Bezafibrate	Bezafibrate	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lipid-regulator
29	Clofibric Acid	Clofibric Acid	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lipid-regulator
30	Fenofibrate	Fenofibrate	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lipid-regulator
31	Gemfibrozil	Gemfibrozil	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lipid-regulator
32	Pravastatin	Pravastatin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lipid-regulator
33	Furosemide	Furosemide	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Diuretic
34	Hydrochlorothiazide	Hydrochlorothiazide	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Diuretic
35	Caffeine	Caffeine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Stimulant
36	Carbamazepine	Carbamazepine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Stimulant
37	Fluoxetine	Fluoxetine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Stimulant
38	Amitriptyline	Amitriptyline	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Anti-depressant
39	Ranitidine	Ranitidine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Histamine-receptor antagonist
40	Famotidine	Famotidine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Histamine-receptor antagonist
41	Lincomycin	Lincomycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lincosamide
42	Clindamycin	Clindamycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Lincosamide
43	Spiramycin	Spiramycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
44	Azithromycin	Azithromycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
45	Clarithromycin	Clarithromycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
46	Tylosin	Tylosin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
47	Erythromycin	Erythromycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
48	Roxithromycin	Roxithromycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
49	Azithromycin	Azithromycin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Macrolide
50	Ofloxacin	Ofloxacin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Quinolone
51	Enrofloxacin	Enrofloxacin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Quinolone
52	Danofloxacin	Danofloxacin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Quinolone
53	Sparfloxacin	Sparfloxacin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Quinolone
54	Flumequine	Flumequine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Quinolone
55	Metronidazole	Metronidazole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Nitroimidazol
56	Ornidazole	Ornidazole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Nitroimidazol
57	Chloramphenicol	Chloramphenicol	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Phenicol
58	Sulfaguanidine	Sulfaguanidine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
59	Sulfadiazine	Sulfadiazine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
60	Sulfamethizole	Sulfamethizole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
61	Sulfamethazine	Sulfamethazine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
62	Sulfamethoxazole	Sulfamethoxazole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
63	Sulfathiazole	Sulfathiazole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
64	Sulfisoxazole	Sulfisoxazole	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
65	Sulfadimethoxine	Sulfadimethoxine	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Sulfonamide
66	Novobiocin	Novobiocin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Aminocoumarin
67	Doxycycline	Doxycycline	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Tetracycline
68	Chlortetracycline	Chlortetracycline	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Tetracycline
69	Oxytetracycline	Oxytetracycline	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Tetracycline
70	Trimethoprim	Trimethoprim	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Diaminopyrimidines
71	Rifampicin	Rifampicin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Rifampicin
72	Methotrexate	Methotrexate	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Other pharmaceuticals
73	Glibenclamide	Glibenclamide	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Other pharmaceuticals
74	Benzophenone-4	Benzophenone-4	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	UV-filter
75	Acesulfame	Acesulfame	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners
76	Saccharin	Saccharin	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners
77	Cyclamate	Cyclamate	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners
78	Aspartame	Aspartame	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners
79	Sucralose	Sucralose	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners
80	Neohesperidin dihydrochalcone	Neohesperidin dihydrochalcone	ng/l	Adenaya, Adenike	Ultra-performance liquid chromatography - triple quadrupole mass spectrometry, (UPLC-QqQMS/MS), Bruker, EVOQ Elite system	Artificial sweeteners

License:

Creative Commons Attribution 4.0 International (CC-BY-4.0)

Size:

1800 data points

Data

Download dataset as tab-delimited text — use the following character encoding:

1 Event	2 Latitude	3 Longitude	4 Date/Time	5 Sal (Thermosalinograph)	6 Temp [°C] (Thermosalinograph)	7 ff [m/s] (Ship Weather Station)	8 Depth water [m]	9 Station	10 Device	11 Samp type	12 Acetaminophen [ng/l] (Anti-inflammatory, Ultra-perf...)	13 Diclofenac [ng/l] (Anti-inflammatory, Ultra-perf...)	14 Fenoprofen [ng/l] (Anti-inflammatory, Ultra-perf...)	15 Ibuprofen [ng/l] (Anti-inflammatory, Ultra-perf...)	16 Indometacin [ng/l] (Anti-inflammatory, Ultra-perf...)	17 Ketoprofen [ng/l] (Anti-inflammatory, Ultra-perf...)	18 Mefenamic acid [ng/l] (Anti-inflammatory, Ultra-perf...)	19 Naproxen [ng/l] (Anti-inflammatory, Ultra-perf...)	20 Phenylbutazone [ng/l] (Anti-inflammatory, Ultra-perf...)	21 Acetylsalicylic acid [ng/l] (Anti-inflammatory, Ultra-perf...)	22 Atenolol [ng/l] (Beta-blocker, Ultra-performan...)	23 Pindolol [ng/l] (Beta-blocker, Ultra-performan...)	24 Nadolol [ng/l] (Beta-blocker, Ultra-performan...)	25 Metoprolol [ng/l] (Beta-blocker, Ultra-performan...)	26 Timolol [ng/l] (Beta-blocker, Ultra-performan...)	27 Propanolol [ng/l] (Beta-blocker, Ultra-performan...)	28 Bezafibrate [ng/l] (Lipid-regulator, Ultra-perfor...)	29 Clofibric Acid [ng/l] (Lipid-regulator, Ultra-perfor...)	30 Fenofibrate [ng/l] (Lipid-regulator, Ultra-perfor...)	31 Gemfibrozil [ng/l] (Lipid-regulator, Ultra-perfor...)	32 Pravastatin [ng/l] (Lipid-regulator, Ultra-perfor...)	33 Furosemide [ng/l] (Diuretic, Ultra-performance l...)	34 Hydrochlorothiazide [ng/l] (Diuretic, Ultra-performance l...)	35 Caffeine [ng/l] (Stimulant, Ultra-performance ...)	36 Carbamazepine [ng/l] (Stimulant, Ultra-performance ...)	37 Fluoxetine [ng/l] (Stimulant, Ultra-performance ...)	38 Amitriptyline [ng/l] (Anti-depressant, Ultra-perfor...)	39 Ranitidine [ng/l] (Histamine-receptor antagonist...)	40 Famotidine [ng/l] (Histamine-receptor antagonist...)	41 Lincomycin [ng/l] (Lincosamide, Ultra-performanc...)	42 Clindamycin [ng/l] (Lincosamide, Ultra-performanc...)	43 Spiramycin [ng/l] (Macrolide, Ultra-performance ...)	44 Azithromycin [ng/l] (Macrolide, Ultra-performance ...)	45 Clarithromycin [ng/l] (Macrolide, Ultra-performance ...)	46 Tylosin [ng/l] (Macrolide, Ultra-performance ...)	47 Erythromycin [ng/l] (Macrolide, Ultra-performance ...)	48 Roxithromycin [ng/l] (Macrolide, Ultra-performance ...)	49 Azithromycin [ng/l] (Macrolide, Ultra-performance ...)	50 Ofloxacin [ng/l] (Quinolone, Ultra-performance ...)	51 Enrofloxacin [ng/l] (Quinolone, Ultra-performance ...)	52 Danofloxacin [ng/l] (Quinolone, Ultra-performance ...)	53 Sparfloxacin [ng/l] (Quinolone, Ultra-performance ...)	54 Flumequine [ng/l] (Quinolone, Ultra-performance ...)	55 Metronidazole [ng/l] (Nitroimidazol, Ultra-performa...)	56 Ornidazole [ng/l] (Nitroimidazol, Ultra-performa...)	57 Chloramphenicol [ng/l] (Phenicol, Ultra-performance l...)	58 Sulfaguanidine [ng/l] (Sulfonamide, Ultra-performanc...)	59 Sulfadiazine [ng/l] (Sulfonamide, Ultra-performanc...)	60 Sulfamethizole [ng/l] (Sulfonamide, Ultra-performanc...)	61 Sulfamethazine [ng/l] (Sulfonamide, Ultra-performanc...)	62 Sulfamethoxazole [ng/l] (Sulfonamide, Ultra-performanc...)	63 Sulfathiazole [ng/l] (Sulfonamide, Ultra-performanc...)	64 Sulfisoxazole [ng/l] (Sulfonamide, Ultra-performanc...)	65 Sulfadimethoxine [ng/l] (Sulfonamide, Ultra-performanc...)	66 Novobiocin [ng/l] (Aminocoumarin, Ultra-performa...)	67 Doxycycline [ng/l] (Tetracycline, Ultra-performan...)	68 Chlortetracycline [ng/l] (Tetracycline, Ultra-performan...)	69 Oxytetracycline [ng/l] (Tetracycline, Ultra-performan...)	70 Trimethoprim [ng/l] (Diaminopyrimidines, Ultra-per...)	71 Rifampicin [ng/l] (Rifampicin, Ultra-performance...)	72 Methotrexate [ng/l] (Other pharmaceuticals, Ultra-...)	73 Glibenclamide [ng/l] (Other pharmaceuticals, Ultra-...)	74 Benzophenone-4 [ng/l] (UV-filter, Ultra-performance ...)	75 Acesulfame [ng/l] (Artificial sweeteners, Ultra-...)	76 Saccharin [ng/l] (Artificial sweeteners, Ultra-...)	77 Cyclamate [ng/l] (Artificial sweeteners, Ultra-...)	78 Aspartame [ng/l] (Artificial sweeteners, Ultra-...)	79 Sucralose [ng/l] (Artificial sweeteners, Ultra-...)	80 Neohesperidin dihydrochalcone [ng/l] (Artificial sweeteners, Ultra-...)
HE614_20-2	53.598791	8.162539	2023-03-12T07:42	30	4	7	0.0	Jade Bay	Van Dorn Sampler	Foam	<0.001	3.510	0.000	52.07	4.360	11.450	7.290	<0.001	<0.001	93.98	<0.001	<0.001	0.000	2.32	<0.001	<0.001	0.440	<0.001	3.940	0.24	<0.001	<0.001	3.410	68.94	5.11	0.130	<0.001	<0.001	<0.001	<0.001	1.110	<0.001	<0.001	4.320	2.890	4.360	<0.001	<0.001	0.000	<0.001	<0.001	<0.001	<0.001	<0.001	45.910	0.790	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	50.770	20.180	<0.001	<0.001	2.390	<0.001	<0.001	<0.001	11.070	19.15	50.32	<0.001	<0.001	3218.35	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:12	30	4	7	0.0	Jade Bay	Glass Plate	SML	<0.001	3.000	18.770	9.24	0.170	21.910	0.310	169.750	<0.001	47.05	<0.001	<0.001	1.060	1.97	<0.001	<0.001	0.260	<0.001	0.710	0.10	<0.001	<0.001	1.770	97.87	4.12	0.130	<0.001	<0.001	<0.001	<0.001	1.570	<0.001	<0.001	1.510	1.700	<0.001	<0.001	<0.001	5.270	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	22.220	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.000	<0.001	<0.001	1.580	<0.001	<0.001	<0.001	56.570	18.70	38.45	<0.001	<0.001	705.02	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:24	30	4	7	0.0	Jade Bay	Van Dorn Sampler	0 cm	<0.001	0.020	<0.001	23.71	<0.001	9.140	0.010	62.900	<0.001	18.18	<0.001	<0.001	1.310	2.72	<0.001	<0.001	0.280	<0.001	0.880	0.13	<0.001	<0.001	3.070	11.22	4.97	<0.001	<0.001	<0.001	<0.001	0.170	0.890	<0.001	<0.001	1.750	1.480	<0.001	<0.001	<0.001	5.520	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.300	<0.001	<0.001	<0.001	<0.001	0.880	<0.001	<0.001	<0.001	9.140	6.280	<0.001	<0.001	1.080	<0.001	<0.001	7.160	24.560	9.46	16.20	141.130	<0.001	1367.00	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:12	30	4	7	0.2	Jade Bay	Van Dorn Sampler	20 cm	<0.001	0.020	<0.001	24.27	<0.001	17.920	<0.001	30.340	<0.001	201.60	<0.001	<0.001	<0.001	1.56	<0.001	<0.001	0.230	<0.001	0.870	0.10	<0.001	<0.001	2.720	6.21	2.94	<0.001	<0.001	<0.001	<0.001	<0.001	0.700	<0.001	<0.001	1.720	0.750	11.380	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.390	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	6.420	7.520	<0.001	<0.001	<0.001	<0.001	<0.001	2.500	16.410	11.98	14.72	205.180	<0.001	1615.79	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:28	30	4	7	0.5	Jade Bay	Van Dorn Sampler	50 cm	<0.001	<0.001	<0.001	19.82	<0.001	0.000	<0.001	<0.001	<0.001	26.08	<0.001	<0.001	<0.001	2.06	<0.001	<0.001	0.260	<0.001	0.730	0.10	<0.001	<0.001	2.260	4.17	4.24	<0.001	<0.001	<0.001	<0.001	<0.001	0.750	<0.001	<0.001	1.670	1.500	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.400	<0.001	<0.001	<0.001	9.090	0.000	<0.001	4.500	1.140	<0.001	<0.001	2.440	15.480	13.77	14.82	212.000	<0.001	1525.09	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:21	30	4	7	1.0	Jade Bay	Van Dorn Sampler	100 cm	<0.001	<0.001	<0.001	24.37	1.090	9.710	0.270	<0.001	<0.001	42.74	<0.001	<0.001	<0.001	2.04	<0.001	<0.001	0.260	<0.001	0.800	0.10	<0.001	<0.001	2.110	5.73	4.13	<0.001	<0.001	<0.001	<0.001	<0.001	0.940	<0.001	<0.001	2.000	0.750	5.960	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	7.820	0.000	<0.001	<0.001	1.470	<0.001	<0.001	2.850	13.230	11.84	14.09	<0.001	<0.001	799.76	<0.001
HE614_20-2	53.598791	8.162539	2023-03-12T07:33	30	4	7	1.5	Jade Bay	Van Dorn Sampler	150 cm	<0.001	<0.001	<0.001	31.61	0.820	6.610	0.250	<0.001	<0.001	34.34	<0.001	<0.001	<0.001	2.43	<0.001	<0.001	0.370	<0.001	2.300	0.11	<0.001	<0.001	2.350	5.69	4.87	0.140	<0.001	<0.001	<0.001	<0.001	0.900	<0.001	<0.001	1.990	1.430	6.060	<0.001	<0.001	7.170	<0.001	<0.001	<0.001	<0.001	0.390	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.140	<0.001	<0.001	<0.001	17.510	0.000	<0.001	<0.001	1.230	<0.001	<0.001	2.240	14.260	9.52	13.88	110.500	<0.001	1509.37	<0.001
HE614_20-2	53.523002	8.580609	2023-03-13T12:49	29	6	10	0.0	Weser Estuary	Glass Plate	SML	<0.001	4.920	<0.001	42.29	3.300	<0.001	0.800	0.000	<0.001	45.39	<0.001	<0.001	<0.001	18.92	<0.001	2.230	0.800	<0.001	2.090	0.11	<0.001	<0.001	6.300	102.31	12.52	0.080	<0.001	<0.001	<0.001	<0.001	3.910	<0.001	<0.001	1.550	1.280	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.400	<0.001	<0.001	<0.001	12.640	<0.001	<0.001	<0.001	1.090	<0.001	<0.001	32.880	89.160	29.28	60.00	63.050	<0.001	805.53	<0.001
HE614_21-1	53.523002	8.580609	2023-03-13T12:53	29	6	10	0.0	Weser Estuary	Van Dorn Sampler	0 cm	<0.001	4.100	<0.001	50.44	3.610	<0.001	1.110	0.490	<0.001	9.94	<0.001	<0.001	<0.001	17.86	<0.001	2.220	1.480	<0.001	0.710	0.15	<0.001	<0.001	8.540	79.03	16.67	0.090	<0.001	<0.001	<0.001	<0.001	4.400	<0.001	<0.001	1.640	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.920	<0.001	<0.001	<0.001	15.180	<0.001	<0.001	<0.001	1.130	<0.001	<0.001	7.250	176.190	23.17	66.81	65.500	1.380	1014.00	<0.001
HE614_21-1	53.523002	8.580609	2023-03-13T12:53	29	6	10	0.2	Weser Estuary	Van Dorn Sampler	20 cm	<0.001	2.950	<0.001	51.94	3.170	<0.001	0.050	1.850	<0.001	7.43	<0.001	<0.001	<0.001	22.13	<0.001	2.230	1.210	<0.001	<0.001	0.14	<0.001	2.650	9.120	81.55	18.23	0.080	<0.001	<0.001	<0.001	<0.001	4.920	<0.001	<0.001	1.750	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.880	<0.001	<0.001	<0.001	9.190	<0.001	<0.001	<0.001	0.930	<0.001	<0.001	3.440	189.820	23.38	77.85	4.320	0.110	755.23	<0.001
HE614_21-1	53.523002	8.580609	2023-03-13T12:57	29	6	10	0.5	Weser Estuary	Van Dorn Sampler	50 cm	<0.001	4.750	<0.001	36.57	1.990	<0.001	0.100	1.750	<0.001	10.82	<0.001	<0.001	<0.001	21.23	<0.001	2.320	1.230	<0.001	0.710	0.14	<0.001	<0.001	8.180	85.10	18.67	0.070	<0.001	<0.001	<0.001	<0.001	5.090	<0.001	<0.001	1.660	0.710	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	1.020	<0.001	<0.001	<0.001	9.650	<0.001	<0.001	<0.001	0.820	<0.001	<0.001	0.000	160.920	31.58	80.50	7.880	<0.001	829.60	<0.001
HE614_21-1	53.523002	8.580609	2023-03-13T12:59	29	6	10	1.0	Weser Estuary	Van Dorn Sampler	100 cm	<0.001	3.500	<0.001	47.68	2.390	<0.001	0.070	1.870	<0.001	16.15	<0.001	<0.001	<0.001	14.42	<0.001	2.250	1.130	<0.001	0.830	0.15	<0.001	<0.001	9.050	64.31	12.02	0.080	<0.001	<0.001	<0.001	<0.001	3.090	<0.001	<0.001	1.690	0.730	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	1.020	<0.001	<0.001	<0.001	6.370	<0.001	<0.001	<0.001	1.010	<0.001	<0.001	13.730	189.560	26.32	75.94	4.600	0.090	700.73	<0.001
HE614_21-1	53.523002	8.580609	2023-03-13T13:01	29	6	10	1.5	Weser Estuary	Van Dorn Sampler	150 cm	<0.001	4.280	<0.001	50.15	2.320	<0.001	0.060	1.860	<0.001	8.49	<0.001	<0.001	<0.001	10.89	<0.001	2.230	0.980	<0.001	0.880	0.13	<0.001	<0.001	9.530	52.41	9.91	0.110	<0.001	<0.001	<0.001	<0.001	2.140	<0.001	<0.001	1.670	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.660	<0.001	<0.001	<0.001	9.900	<0.001	<0.001	<0.001	1.130	<0.001	<0.001	7.100	166.940	34.41	71.93	5.040	<0.001	811.10	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:05	31	6	8	0.0	NS_7	Glass Plate	SML	<0.001	1.390	<0.001	13.39	0.810	<0.001	1.380	<0.001	<0.001	64.57	<0.001	<0.001	<0.001	2.26	<0.001	<0.001	0.160	<0.001	1.540	0.18	<0.001	<0.001	0.790	52.54	3.53	1.430	<0.001	<0.001	<0.001	<0.001	0.710	<0.001	<0.001	1.390	2.070	3.200	<0.001	<0.001	4.350	<0.001	8.250	<0.001	<0.001	<0.001	<0.001	2.980	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	4.500	<0.001	<0.001	<0.001	1.290	<0.001	<0.001	<0.001	0.630	7.54	10.73	<0.001	<0.001	1455.09	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:21	31	6	8	0.0	NS_7	Van Dorn Sampler	0 cm	<0.001	<0.001	<0.001	15.82	<0.001	<0.001	<0.001	<0.001	<0.001	127.30	<0.001	<0.001	<0.001	1.93	<0.001	<0.001	<0.001	<0.001	1.730	0.15	<0.001	<0.001	0.530	15.99	3.40	1.590	<0.001	<0.001	0.460	<0.001	0.410	<0.001	<0.001	1.790	1.430	5.260	<0.001	<0.001	0.000	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	4.830	<0.001	<0.001	<0.001	1.030	<0.001	<0.001	13.160	<0.001	4.53	12.16	<0.001	<0.001	1255.75	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:25	31	6	8	0.2	NS_7	Van Dorn Sampler	20 cm	<0.001	<0.001	<0.001	11.65	<0.001	<0.001	<0.001	<0.001	<0.001	10.10	1.930	<0.001	<0.001	2.04	<0.001	2.900	<0.001	<0.001	<0.001	0.13	<0.001	<0.001	0.390	17.04	3.70	1.510	<0.001	<0.001	<0.001	<0.001	0.620	<0.001	<0.001	1.790	2.170	4.690	<0.001	<0.001	5.490	<0.001	11.140	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	7.960	<0.001	<0.001	<0.001	1.110	<0.001	<0.001	12.300	<0.001	3.16	5.76	<0.001	<0.001	1695.88	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:28	31	6	8	0.5	NS_7	Van Dorn Sampler	50 cm	<0.001	<0.001	<0.001	11.70	<0.001	<0.001	<0.001	<0.001	<0.001	18.77	<0.001	<0.001	<0.001	1.69	<0.001	<0.001	<0.001	<0.001	1.350	0.12	<0.001	<0.001	<0.001	5.12	3.13	<0.001	<0.001	<0.001	<0.001	<0.001	0.330	<0.001	<0.001	1.550	3.330	5.120	<0.001	<0.001	3.560	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	4.040	<0.001	<0.001	<0.001	1.040	<0.001	<0.001	10.130	<0.001	6.31	6.79	<0.001	<0.001	1383.60	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:30	31	6	8	1.0	NS_7	Van Dorn Sampler	100 cm	<0.001	<0.001	<0.001	10.96	0.240	<0.001	1.720	<0.001	<0.001	68.69	<0.001	<0.001	<0.001	1.77	<0.001	<0.001	<0.001	<0.001	0.530	0.09	<0.001	<0.001	0.110	6.23	3.37	<0.001	<0.001	<0.001	<0.001	<0.001	0.470	<0.001	<0.001	1.340	0.600	3.930	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	7.050	<0.001	<0.001	<0.001	0.860	<0.001	<0.001	8.200	1.930	3.51	4.21	<0.001	<0.001	1542.28	<0.001
HE614_28-6	53.852357	7.621076	2023-03-17T13:33	31	6	8	1.5	NS_7	Van Dorn Sampler	150 cm	<0.001	<0.001	<0.001	10.80	<0.001	<0.001	<0.001	<0.001	<0.001	17.09	<0.001	<0.001	<0.001	1.61	<0.001	<0.001	<0.001	<0.001	0.240	0.11	<0.001	<0.001	<0.001	8.97	3.21	<0.001	<0.001	<0.001	0.160	<0.001	0.390	<0.001	<0.001	0.700	1.110	4.310	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	9.370	<0.001	<0.001	<0.001	0.500	<0.001	<0.001	5.050	<0.001	3.72	5.72	<0.001	<0.001	2001.34	<0.001
HE614_32-2	54.868190	7.245698	2023-03-19T08:00	33	6	8	0.0	NS_8	Glass Plate	SML	<0.001	1.286	<0.001	15.50	0.498	<0.001	0.200	<0.001	<0.001	87.90	<0.001	<0.001	<0.001	0.70	<0.001	<0.001	0.200	<0.001	1.482	0.80	<0.001	<0.001	1.000	100.10	1.70	1.492	<0.001	<0.001	0.384	<0.001	1.366	<0.001	<0.001	1.302	1.100	9.300	<0.001	<0.001	<0.001	<0.001	3.900	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.500	<0.001	<0.001	<0.001	7.000	9.518	<0.001	<0.001	0.722	<0.001	<0.001	3.980	8.500	9.20	25.10	<0.001	<0.001	649.30	<0.001
HE614_32-2	54.868190	7.245698	2023-03-19T08:12	33	6	8	0.0	NS_8	Van Dorn Sampler	0 cm	<0.001	<0.001	<0.001	13.50	<0.001	<0.001	<0.001	<0.001	<0.001	81.10	1.368	<0.001	<0.001	0.70	<0.001	<0.001	0.200	<0.001	0.516	0.50	<0.001	<0.001	0.900	4.00	1.70	1.442	<0.001	<0.001	<0.001	<0.001	1.268	<0.001	<0.001	1.294	0.900	2.800	<0.001	<0.001	<0.001	<0.001	3.100	<0.001	<0.001	<0.001	2.044	<0.001	<0.001	<0.001	<0.001	<0.001	0.200	<0.001	<0.001	<0.001	13.700	<0.001	<0.001	<0.001	0.758	<0.001	<0.001	<0.001	7.400	8.90	15.80	<0.001	<0.001	1806.60	<0.001
HE614_32-2	54.868190	7.245698	2023-03-19T08:14	33	6	8	0.2	NS_8	Van Dorn Sampler	20 cm	<0.001	<0.001	<0.001	15.10	<0.001	<0.001	<0.001	<0.001	<0.001	71.90	<0.001	<0.001	<0.001	0.80	<0.001	<0.001	0.200	<0.001	0.526	0.40	<0.001	<0.001	1.100	17.00	1.70	1.386	<0.001	<0.001	0.320	<0.001	1.286	<0.001	<0.001	1.298	0.800	6.500	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.100	<0.001	<0.001	<0.001	6.400	<0.001	<0.001	<0.001	0.766	<0.001	<0.001	6.350	3.100	7.70	14.60	<0.001	<0.001	1628.20	<0.001
HE614_32-2	54.868190	7.245698	2023-03-19T08:16	33	6	8	0.5	NS_8	Van Dorn Sampler	50 cm	<0.001	<0.001	<0.001	14.30	<0.001	<0.001	<0.001	<0.001	<0.001	26.10	<0.001	<0.001	<0.001	0.90	<0.001	<0.001	0.100	<0.001	0.530	0.30	<0.001	<0.001	0.900	6.90	1.90	1.426	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	1.224	1.000	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.100	<0.001	<0.001	<0.001	23.800	<0.001	<0.001	<0.001	1.048	<0.001	<0.001	<0.001	1.600	6.90	11.60	<0.001	<0.001	1866.30	<0.001
HE614_32-2	54.868190	7.245698	2023-03-19T08:16	33	6	8	1.5	NS_8	Van Dorn Sampler	150 cm	<0.001	<0.001	<0.001	12.20	<0.001	<0.001	<0.001	<0.001	<0.001	33.70	1.388	<0.001	<0.001	0.80	<0.001	<0.001	0.200	<0.001	0.426	0.30	<0.001	<0.001	1.100	18.80	1.60	1.490	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	1.302	1.300	6.400	<0.001	<0.001	<0.001	<0.001	10.300	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	26.000	<0.001	<0.001	<0.001	0.848	<0.001	<0.001	<0.001	10.500	10.60	15.80	<0.001	<0.001	977.00	<0.001