Kötke Danijela danijela.koetke@hzg.de Gandrass Juergen juergen.gandrass@hereon.de 0000-0001-6083-4494 Xie Zhiyong zhiyong.xie@hzg.de 0000-0001-8997-3930 Ebinghaus Ralf ralf.ebinghaus@hereon.de 2021 Prioritised pharmaceuticals in German estuaries and coastal waters in 2015/2016 dataset https://doi.org/10.1594/PANGAEA.929500 2021-03-22T09:04:31 In this study a target analysis approach with method detection limits down to 0.01 ng L−1 was developed in order to determine ultra-trace pharmaceuticals in seawater of the German coast and their estuaries. The selection of target analytes based on a prioritisation commissioned by the German Environmental Agency considering occurrence in German surface waters, production volumes and ecotoxicological data. Using ultra-high pressure liquid chromatography coupled to a triple quadrupole mass spectrometer equipped with an electrospray ionisation source 21 prioritised pharmaceuticals out of seven therapeutical classes (antibiotics, iodinated X-ray contrast media (ICM), analgesics, lipid reducers, antiepileptics, anticonvulsants, beta-blockers) have been detected in the low to medium ng L−1-range. The most frequently measured substance groups in the German Baltic Sea and German Bight are the ICM, represented by the non-ionic ICM iomeprol (German Bightmax: 207 ng L−1; Baltic Seamax: 34.5 ng L−1) and the ionic ICM amidotrizoic acid (German Bight: 86.9 ng L−1), respectively. The same pattern of substance distribution could be detected in the German Bight, the German Baltic Sea and their inflows with lower concentrations in the offshore region that are partly a result of dilution with marine water. Pharmaceuticals entering the estuaries and coastal regions are an environmental issue since data on the ecotoxicological effects on aquatic marine organisms is limited. Especially the antibiotics clarithromycin and sulfamethoxazole could be ecotoxicologically/environmentally critical. Kötke Danijela danijela.koetke@hzg.de Gandrass Juergen juergen.gandrass@hereon.de 0000-0001-6083-4494 Xie Zhiyong zhiyong.xie@hzg.de 0000-0001-8997-3930 Ebinghaus Ralf ralf.ebinghaus@hereon.de 2019 Prioritised pharmaceuticals in German estuaries and coastal waters: Occurrence and environmental risk assessment journal article Environmental Pollution 255 https://doi.org/10.1016/j.envpol.2019.113161 113161 8.078 14.535 53.036 54.823 11.01677758490566 54.066198849056605 2015-05-29T12:00:00 2016-03-16T16:40:00 0.0 0.0 not specified HZG Helmholtz-Zentrum Geesthacht, Institute of Coastal Research https://www.hereon.de/ Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research HZG http://www.hzg.de/index.html.en https://ror.org/03qjp1d79 LP20150529_Stat_E1 53.843 8.941 German Bight, North Sea 2015-06-02T11:40:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_E2 53.874 9.238 German Bight, North Sea 2015-06-02T12:35:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_E3 53.745 9.407 German Bight, North Sea 2015-06-02T13:30:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_E4 53.605 9.576 German Bight, North Sea 2015-06-02T14:32:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_E5 53.55 9.819 German Bight, North Sea 2015-06-02T15:31:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_GB1 53.901 8.686 German Bight, North Sea 2015-05-29T12:00:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_GB2 53.964 8.522 German Bight, North Sea 2015-05-29T12:45:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_GB3 53.903 8.078 German Bight, North Sea 2015-05-29T14:48:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_GB4 53.754 8.189 German Bight, North Sea 2015-05-29T16:20:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_GB5 53.663 8.38 German Bight, North Sea 2015-05-29T17:25:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_W1 53.459 8.493 German Bight, North Sea 2015-05-30T15:20:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_W2 53.369 8.501 German Bight, North Sea 2015-05-30T14:50:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_W3 53.279 8.488 German Bight, North Sea 2015-05-30T14:13:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS LP20150529_Stat_W4 53.188 8.537 German Bight, North Sea 2015-05-30T13:17:00 LP20150529 LP20150529 Cuxhaven, Germany 2015-05-29T00:00:00 2015-05-29 Oortkaten, Germany 2015-06-02T00:00:00 2015-06-02 Ludwig Prandtl DAOH 8332320 Ludwig Prandtl DAOH 8332320 Water sample WS SB1508_Stat_BS1 53.976 14.146 German Bight, North Sea 2015-09-01T19:00:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS2 54.06 14.0 German Bight, North Sea 2015-09-01T17:45:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS3 54.348 13.744 German Bight, North Sea 2015-09-02T11:40:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS4 54.404 13.618 German Bight, North Sea 2015-09-02T10:40:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS5 54.318 13.095 German Bight, North Sea 2015-09-02T08:55:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS6 54.455 12.571 German Bight, North Sea 2015-09-03T10:30:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS7 54.353 12.383 German Bight, North Sea 2015-09-03T11:50:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS8 54.181 12.091 German Bight, North Sea 2015-09-03T13:50:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS9 54.156 11.763 German Bight, North Sea 2015-09-03T16:05:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS10 53.992 11.374 German Bight, North Sea 2015-09-03T18:00:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS11 53.948 11.348 German Bight, North Sea 2015-09-03T20:00:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS12 53.941 11.252 German Bight, North Sea 2015-09-03T19:30:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS13 53.97 10.883 German Bight, North Sea 2015-09-04T11:45:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS15 54.141 10.965 German Bight, North Sea 2015-09-04T13:30:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS16 54.356 11.092 German Bight, North Sea 2015-09-04T16:35:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS19 54.427 10.172 German Bight, North Sea 2015-09-05T11:35:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS20 54.462 9.843 German Bight, North Sea 2015-09-10T10:30:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS21 54.66 9.935 German Bight, North Sea 2015-09-05T13:50:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_BS22 54.823 9.654 German Bight, North Sea 2015-09-05T16:05:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_O1 53.036 14.312 German Bight, North Sea 2015-08-23T09:06:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_O2 53.383 14.535 German Bight, North Sea 2015-08-23T12:20:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_O3 53.736 14.174 German Bight, North Sea 2015-08-23T14:55:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1508_Stat_P1 53.86 13.69 German Bight, North Sea 2015-08-23T18:35:00 SB1508 SB1508 Schwedt/Oder 2015-08-23T00:00:00 2015-08-23 Eckernförde 2015-09-10T00:00:00 2015-09-10 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS4 54.40355 13.61794 German Bight, North Sea 2016-03-15T11:00:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS5 54.31843 13.09527 German Bight, North Sea 2016-03-15T09:45:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS6 54.45522 12.57057 German Bight, North Sea 2016-03-15T12:15:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS7 54.35272 12.38314 German Bight, North Sea 2016-03-15T13:30:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS8 54.18055 12.09059 German Bight, North Sea 2016-03-15T14:50:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS9 54.15592 11.76279 German Bight, North Sea 2016-03-15T16:30:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS11 53.94818 11.34778 German Bight, North Sea 2016-03-15T18:00:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS14 54.001369 10.783602 German Bight, North Sea 2016-03-16T09:05:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS15 54.14124 10.96468 German Bight, North Sea 2016-03-16T10:00:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS16 54.35593 11.09159 German Bight, North Sea 2016-03-16T11:30:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS17 54.32498 10.66704 German Bight, North Sea 2016-03-16T12:10:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS18 54.41575 10.41542 German Bight, North Sea 2016-03-16T12:55:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS19 54.42723 10.17164 German Bight, North Sea 2016-03-16T14:00:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS20 54.46199 9.84339 German Bight, North Sea 2016-03-16T15:10:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS21 54.65958 9.93451 German Bight, North Sea 2016-03-16T15:55:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS SB1603_Stat_BS22 54.8229 9.65426 German Bight, North Sea 2016-03-16T16:40:00 SB1603 SB1603 Stralsund 2016-03-15T00:00:00 2016-03-15 Langballingholz 2016-03-16T00:00:00 2016-03-16 Kötke, Danijela Kötke, Danijela Water sample WS 1176 CC-BY-4.0 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/ Date/Time = local time Temperature, water; Salinity and pH method:For campaigns SB1603 and SB1508: oxygen, conductivity, temperature, pH; Multimeter 3430 WTW. For campaign LP20150529: Measurement by on-line-in-situ FerryBox-System. Event label Event Kötke Danijela danijela.koetke@hzg.de Event Campaign of event Campaign Kötke Danijela danijela.koetke@hzg.de Campaign Latitude of event Latitude Kötke Danijela danijela.koetke@hzg.de Latitude Longitude of event Longitude Kötke Danijela danijela.koetke@hzg.de Longitude Date/Time of event Date/Time Kötke Danijela danijela.koetke@hzg.de Date/Time DEPTH, water Depth water m depth http://purl.obolibrary.org/obo/PATO_0001595 water http://purl.obolibrary.org/obo/CHEBI_15377 Length L http://dbpedia.org/resource/Length Kötke Danijela danijela.koetke@hzg.de Depth water [m] Temperature, water Temp °C Temperature Θ http://dbpedia.org/resource/Temperature water http://purl.obolibrary.org/obo/CHEBI_15377 See description in dataset comment Kötke Danijela danijela.koetke@hzg.de measured in water column Temp [°C] Salinity Sal salinity http://purl.obolibrary.org/obo/PATO_0085001 See description in dataset comment Kötke Danijela danijela.koetke@hzg.de measured in water column Sal pH pH See description in dataset comment Kötke Danijela danijela.koetke@hzg.de measured in water column pH Nadolol Nadolol ng/l nadolol http://purl.obolibrary.org/obo/CHEBI_7444 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.03ng/l Nadolol [ng/l] Paracetamol Paracetamol ng/l paracetamol http://purl.obolibrary.org/obo/CHEBI_46195 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.14ng/l, limit of quantification for SB1603 and SB1508: 0.03ng/l, limit of quantification for LP20150529: 0.46ng/l Paracetamol [ng/l] Carbamazepine Carbamazepine ng/l carbamazepine http://purl.obolibrary.org/obo/CHEBI_3387 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.11ng/l, limit of detection for LP20150529: 0.33ng/l, limit of quantification for SB1603 and SB1508: 0.38ng/l, limit of quantification for LP20150529: 1.12ng/l Carbamazepine [ng/l] Diclofenac Diclofenac ng/l diclofenac http://purl.obolibrary.org/obo/CHEBI_47381 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.03ng/l, limit of detection for LP20150529: 0.18ng/l, limit of quantification for SB1603 and SB1508: 0.1ng/l, limit of quantification for LP20150529: 0.61ng/l Diclofenac [ng/l] Iohexol Iohexol ng/l iohexol http://purl.obolibrary.org/obo/CHEBI_31709 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.17ng/l, limit of detection for LP20150529: 0.34ng/l, limit of quantification for SB1603 and SB1508: 0.26ng/l, limit of quantification for LP20150529: 0.53ng/l Iohexol [ng/l] Iopromide Iopromide ng/l iopromide http://purl.obolibrary.org/obo/CHEBI_63578 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.17ng/l, limit of detection for LP20150529: 0.3ng/l, limit of quantification for SB1603 and SB1508: 0.27ng/l, limit of quantification for LP20150529: 0.85ng/l Iopromide [ng/l] Lincomycin Lincomycin ng/l lincomycin http://purl.obolibrary.org/obo/CHEBI_6472 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.01ng/l Lincomycin [ng/l] Propranolol Propranolol ng/l propranolol http://purl.obolibrary.org/obo/CHEBI_8499 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.02ng/l, limit of detection for LP20150529: 0.03ng/l, limit of quantification for SB1603 and SB1508: 0.07ng/l, limit of quantification for LP20150529: 0.09ng/l Propranolol [ng/l] Sulfadimethoxine Sulfadimethoxine ng/l sulfadimethoxine http://purl.obolibrary.org/obo/CHEBI_32161 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.04ng/l Sulfadimethoxine [ng/l] Sulfamethoxazole Sulfamethoxazole ng/l sulfamethoxazole http://purl.obolibrary.org/obo/CHEBI_9332 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.02ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.07ng/l Sulfamethoxazole [ng/l] Bezafibrate Bezafibrate ng/l bezafibrate http://purl.obolibrary.org/obo/CHEBI_47612 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.03ng/l, limit of detection for LP20150529: 0.06ng/l, limit of quantification for SB1603 and SB1508: 0.18ng/l, limit of quantification for LP20150529: 0.36ng/l Bezafibrate [ng/l] Clarithromycin Clarithromycin ng/l clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.03ng/l Clarithromycin [ng/l] Erythromycin Erythromycin ng/l erythromycin http://purl.obolibrary.org/obo/CHEBI_48923 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: <0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.01ng/l, limit of quantification for LP20150529: 0.01ng/l Erythromycin [ng/l] Iomeprol Iomeprol ng/l iomeprol http://purl.obolibrary.org/obo/CHEBI_31710 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.16ng/l, limit of detection for LP20150529: 0.99ng/l, limit of quantification for SB1603 and SB1508: 0.4ng/l, limit of quantification for LP20150529: 3.29ng/l Iomeprol [ng/l] Iopamidol Iopamidol ng/l iopamidol http://purl.obolibrary.org/obo/CHEBI_31711 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.15ng/l, limit of detection for LP20150529: 0.34ng/l, limit of quantification for SB1603 and SB1508: 0.34ng/l, limit of quantification for LP20150529: 0.53ng/l Iopamidol [ng/l] Primidone Primidone ng/l primidone http://purl.obolibrary.org/obo/CHEBI_8412 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.04ng/l, limit of detection for LP20150529: 0.1ng/l, limit of quantification for SB1603 and SB1508: 0.13ng/l, limit of quantification for LP20150529: 0.34ng/l Primidone [ng/l] Roxithromycin Roxithromycin ng/l roxithromycin http://purl.obolibrary.org/obo/CHEBI_48844 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: 0.02ng/l, limit of quantification for SB1603 and SB1508: 0.04ng/l, limit of quantification for LP20150529: 0.06ng/l Roxithromycin [ng/l] Sulfamethazine Sulfamethazine ng/l sulfamethazine http://purl.obolibrary.org/obo/CHEBI_102265 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.07ng/l, limit of detection for LP20150529: 0.33ng/l, limit of quantification for SB1603 and SB1508: 0.22ng/l, limit of quantification for LP20150529: 1.09ng/l Sulfamethazine [ng/l] Tiamulin Tiamulin ng/l tiamulin http://purl.obolibrary.org/obo/CHEBI_44137 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for SB1603 and SB1508: 0.01ng/l, limit of detection for LP20150529: <0.01ng/l, limit of quantification for SB1603 and SB1508: 0.02ng/l, limit of quantification for LP20150529: 0.02ng/l Tiamulin [ng/l] Amidotrizoic acid Amidotrizoic acid ng/l amidotrizoic acid http://purl.obolibrary.org/obo/CHEBI_53691 Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for LP20150529: 0.05ng/l, limit of quantification for LP20150529: 0.35ng/l Amidotrizoic acid [ng/l] Ioxitalamic acid Ioxitalamic acid ng/l Density http://dbpedia.org/resource/Density Solid-phase extraction (SPE) and cleanup, coupled liquid chromatography tandem mass spectrometry (LC-MS/MS) Kötke Danijela danijela.koetke@hzg.de measured in water column, limit of detection for LP20150529: 0.06ng/l, limit of quantification for LP20150529: 0.36ng/l Ioxitalamic acid [ng/l] citable author31031 author34642 author62334 author62335 basis4658 campaign3373612 campaign3373619 campaign3373624 campaign47791 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