<?xml version="1.0" encoding="UTF-8"?><md:MetaData xmlns:md="http://www.pangaea.de/MetaData" version="2026-04-13">
<md:citation id="dataset898930">
<md:author id="dataset.author68229">
<md:lastName>Falfushynska</md:lastName>
<md:firstName>Halina</md:firstName>
<md:orcid>0000-0003-3058-4919</md:orcid>
</md:author>
<md:author id="dataset.author68230">
<md:lastName>Sokolov</md:lastName>
<md:firstName>Eugene P</md:firstName>
</md:author>
<md:author id="dataset.author64560">
<md:lastName>Haider</md:lastName>
<md:firstName>Fouzia</md:firstName>
<md:eMail>fouzia.haider@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-5388-6453</md:orcid>
</md:author>
<md:author id="dataset.author68231">
<md:lastName>Oppermann</md:lastName>
<md:firstName>Christina</md:firstName>
<md:eMail>christina.oppermann@uni-rostock.de</md:eMail>
</md:author>
<md:author id="dataset.author54000">
<md:lastName>Kragl</md:lastName>
<md:firstName>Udo</md:firstName>
<md:orcid>0000-0002-2507-7472</md:orcid>
</md:author>
<md:author id="dataset.author53999">
<md:lastName>Ruth</md:lastName>
<md:firstName>Wolfgang</md:firstName>
</md:author>
<md:author id="dataset.author68232">
<md:lastName>Stock</md:lastName>
<md:firstName>Marius</md:firstName>
</md:author>
<md:author id="dataset.author68233">
<md:lastName>Glufke</md:lastName>
<md:firstName>Sabrina</md:firstName>
</md:author>
<md:author id="dataset.author68234">
<md:lastName>Winkel</md:lastName>
<md:firstName>Eileen J</md:firstName>
</md:author>
<md:author id="dataset.author57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:author>
<md:year>2019</md:year>
<md:title>Effect of atorvastatin on the xenobioitic detoxification of blue mussels, Mytilus edulis</md:title>
<md:type id="dataset.reftype10" includeInCitation="true">dataset</md:type>
<md:URI>https://doi.org/10.1594/PANGAEA.898930</md:URI>
<md:dateTime>2019-03-04T10:35:08</md:dateTime>
</md:citation>
<md:abstract>Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels – Mytilus edulis. In this data set, we presents the effect of atorvastatin (ATO) on detoxification of Mytilus edulis.</md:abstract>
<md:reference dataciteRelType="References" group="210" id="ref98788" relationType="Related to" relationTypeId="12">
<md:author id="ref98788.author68229">
<md:lastName>Falfushynska</md:lastName>
<md:firstName>Halina</md:firstName>
<md:orcid>0000-0003-3058-4919</md:orcid>
</md:author>
<md:author id="ref98788.author68230">
<md:lastName>Sokolov</md:lastName>
<md:firstName>Eugene P</md:firstName>
</md:author>
<md:author id="ref98788.author64560">
<md:lastName>Haider</md:lastName>
<md:firstName>Fouzia</md:firstName>
<md:eMail>fouzia.haider@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-5388-6453</md:orcid>
</md:author>
<md:author id="ref98788.author68231">
<md:lastName>Oppermann</md:lastName>
<md:firstName>Christina</md:firstName>
<md:eMail>christina.oppermann@uni-rostock.de</md:eMail>
</md:author>
<md:author id="ref98788.author54000">
<md:lastName>Kragl</md:lastName>
<md:firstName>Udo</md:firstName>
<md:orcid>0000-0002-2507-7472</md:orcid>
</md:author>
<md:author id="ref98788.author53999">
<md:lastName>Ruth</md:lastName>
<md:firstName>Wolfgang</md:firstName>
</md:author>
<md:author id="ref98788.author68232">
<md:lastName>Stock</md:lastName>
<md:firstName>Marius</md:firstName>
</md:author>
<md:author id="ref98788.author68233">
<md:lastName>Glufke</md:lastName>
<md:firstName>Sabrina</md:firstName>
</md:author>
<md:author id="ref98788.author68234">
<md:lastName>Winkel</md:lastName>
<md:firstName>Eileen J</md:firstName>
</md:author>
<md:author id="ref98788.author57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:author>
<md:year>2019</md:year>
<md:title>Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis</md:title>
<md:type id="ref98788.reftype1">journal article</md:type>
<md:source id="ref98788.journal1383" relatedTermIds="33987,34066" type="journal">Aquatic Toxicology</md:source>
<md:volume>208</md:volume>
<md:URI>https://doi.org/10.1016/j.aquatox.2018.12.022</md:URI>
<md:pages>47-61</md:pages>
</md:reference>
<md:extent>
<md:topoType id="topotype1">not specified</md:topoType>
</md:extent>
<md:size unit="data points">143</md:size>
<md:license id="license21">
<md:label>CC-BY-4.0</md:label>
<md:name>Creative Commons Attribution 4.0 International</md:name>
<md:URI>https://creativecommons.org/licenses/by/4.0/</md:URI>
</md:license>
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<md:parameter id="col0.ds13605387.param7053">
<md:name>Species</md:name>
<md:shortName>Species</md:shortName>
<md:URI>https://en.wikipedia.org/wiki/Species</md:URI>
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<md:name>species</md:name>
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<md:PI id="col0.ds13605387.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
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<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:comment>Exposure to Atorvastatin</md:comment>
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<md:name>Time in weeks</md:name>
<md:shortName>Time weeks</md:shortName>
<md:unit>weeks</md:unit>
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<md:PI id="col2.ds13605389.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:comment>Exposure time</md:comment>
<md:caption>Time weeks [weeks] (Exposure time)</md:caption>
</md:matrixColumn>
<md:matrixColumn col="3" id="col3.ds13605390" source="data" type="string">
<md:parameter id="col3.ds13605390.param16065">
<md:name>Sample ID</md:name>
<md:shortName>Sample ID</md:shortName>
</md:parameter>
<md:PI id="col3.ds13605390.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
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<md:caption>Sample ID</md:caption>
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<md:matrixColumn col="4" format="#0.000" id="col4.ds13605391" source="data" type="numeric">
<md:parameter id="col4.ds13605391.param101276">
<md:name>Mytilus edulis, mass</md:name>
<md:shortName>M. edulis m</md:shortName>
<md:unit>g</md:unit>
<md:URI>http://www.marinespecies.org/aphia.php?p=taxdetails&amp;id=140480</md:URI>
<md:term endOffset="14" fragment="1" id="col4.ds13605391.param101276.term1052997" semanticURI="urn:lsid:marinespecies.org:taxname:140480" startOffset="0" terminologyId="1" terminologyLabel="WORMS">
<md:name>Mytilus edulis</md:name>
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<md:name>Mass</md:name>
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<md:PI id="col4.ds13605391.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:comment>Total body mass</md:comment>
<md:caption>M. edulis m [g] (Total body mass)</md:caption>
</md:matrixColumn>
<md:matrixColumn col="5" format="#0.000" id="col5.ds13605392" source="data" type="numeric">
<md:parameter id="col5.ds13605392.param169605">
<md:name>Rhodamine B efflux rate</md:name>
<md:shortName>RB efflux rate</md:shortName>
<md:unit>nmol/h/g</md:unit>
<md:term id="col5.ds13605392.param169605.term44032" terminologyId="13" terminologyLabel="PAN-Quantity">
<md:name>Specific Activity</md:name>
<md:URI>http://search.ebscohost.com/login.aspx?direct=true&amp;db=nlebk&amp;AN=98508&amp;site=ehost-live&amp;ebv=EB&amp;ppid=pp_610</md:URI>
</md:term>
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<md:PI id="col5.ds13605392.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:caption>RB efflux rate [nmol/h/g]</md:caption>
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<md:matrixColumn col="6" format="#0.000" id="col6.ds13605393" source="data" type="numeric">
<md:parameter id="col6.ds13605393.param169604">
<md:name>P-glycoprotein activity</md:name>
<md:shortName>PgP activity</md:shortName>
<md:unit>nmol/h/g</md:unit>
<md:term id="col6.ds13605393.param169604.term44032" terminologyId="13" terminologyLabel="PAN-Quantity">
<md:name>Specific Activity</md:name>
<md:URI>http://search.ebscohost.com/login.aspx?direct=true&amp;db=nlebk&amp;AN=98508&amp;site=ehost-live&amp;ebv=EB&amp;ppid=pp_610</md:URI>
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<md:PI id="col6.ds13605393.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:caption>PgP activity [nmol/h/g]</md:caption>
</md:matrixColumn>
<md:matrixColumn col="7" id="col7.ds13605394" source="data" type="string">
<md:parameter id="col7.ds13605394.param1570">
<md:name>Comment</md:name>
<md:shortName>Comment</md:shortName>
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<md:PI id="col7.ds13605394.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
</md:PI>
<md:comment>PgP activity</md:comment>
<md:caption>Comment (PgP activity)</md:caption>
</md:matrixColumn>
<md:matrixColumn col="8" format="#0.000" id="col8.ds13605395" source="data" type="numeric">
<md:parameter id="col8.ds13605395.param169603">
<md:name>Diffusion efflux rate</md:name>
<md:shortName>Diff efflux rate</md:shortName>
<md:unit>nmol/h/g</md:unit>
<md:term endOffset="21" fragment="1" id="col8.ds13605395.param169603.term47756" startOffset="0" terminologyId="18" terminologyLabel="PAN-MicroBio">
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<md:name>Specific Activity</md:name>
<md:URI>http://search.ebscohost.com/login.aspx?direct=true&amp;db=nlebk&amp;AN=98508&amp;site=ehost-live&amp;ebv=EB&amp;ppid=pp_610</md:URI>
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<md:PI id="col8.ds13605395.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
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<md:caption>Diff efflux rate [nmol/h/g]</md:caption>
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<md:matrixColumn col="9" id="col9.ds13605396" source="data" type="string">
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<md:name>Comment</md:name>
<md:shortName>Comment</md:shortName>
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<md:PI id="col9.ds13605396.pi57529">
<md:lastName>Sokolova</md:lastName>
<md:firstName>Inna M</md:firstName>
<md:eMail>inna.sokolova@uni-rostock.de</md:eMail>
<md:orcid>0000-0002-2068-4302</md:orcid>
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<md:comment>Outlier</md:comment>
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<md:keywords>
<md:techKeyword type="autoGenerated">citable</md:techKeyword>
<md:keyword id="keywords.term47544" type="fromDatabase">Atorvastatin</md:keyword>
<md:keyword id="keywords.term41845" type="fromDatabase">Mytilus edulis</md:keyword>
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