Routti, Heli; Nyman, Madeleine; Jenssen, Bjørn Munro; Bäckman, Christina; Koistinen, Jaana; Gabrielsen, Geir W (2008): Concentrations of PCBs, DDT and thyroid hormones in gray (Halichoerus grypus) and ringed (Phoca hispida) seals [dataset publication series]. PANGAEA, https://doi.org/10.1594/PANGAEA.819419, Supplement to: Routti, H et al. (2008): Bone-related effects of contaminants in seals may be associated with vitamin D and thyroid hormones. Environmental Toxicology and Chemistry, 27(4), 873, https://doi.org/10.1897/07-139.1
Always quote citation above when using data! You can download the citation in several formats below.
Abstract:
The high levels of polychlorinated biphenyls (PCBs) and DDT in gray seal (Halichoerus grypus) and ringed seal (Phoca hispida botnica) in the Baltic Sea have been associated with pathological disruptions, including bone lesions and reproductive failures. The underlying environmental and toxicological mechanisms leading to these pathological changes are not yet fully understood. The present study investigated the relationship between the individual contaminant load and bone- and thyroid-related effects in adult gray seals (n = 30) and ringed seals (n = 46) in the highly contaminated Baltic Sea and in reference areas (Sable Island, Canada, and Svalbard, Norway). In the gray seals, multivariate and correlation analyses revealed a clear relationship between circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D), calcium, phosphate, and thyroid hormone (TH) levels and hepatic PCB and DDT load, which suggests contaminant-mediated disruption of the bone and thyroid homeostasis. Contaminants may depress 1,25(OH)2D levels or lead to hyperthyroidism, which may cause bone resorption. In the ringed seals, associations between circulating 1,25(OH)2D, THs, and hepatic contaminants were less prominent. These results suggest that bone lesions observed in the Baltic gray seals may be associated with contaminant-mediated vitamin D and thyroid disruption.
Project(s):
Coverage:
Median Latitude: 62.047433 * Median Longitude: 3.831833 * South-bound Latitude: 43.950000 * West-bound Longitude: -59.916000 * North-bound Latitude: 78.900000 * East-bound Longitude: 24.333000
Comment:
Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150
License:
Creative Commons Attribution 3.0 Unported (CC-BY-3.0)
Size:
2 datasets
Download Data
Datasets listed in this publication series
- Routti, H; Nyman, M; Jenssen, BM et al. (2008): (Table 1) Age, condition index, and levels of hepatic PCBs and DDTs, circulating calcium, phosphate, and retinol in gray (Halichoerus grypus) and ringed (Phoca hispida) seals. https://doi.org/10.1594/PANGAEA.819417
- Routti, H; Nyman, M; Jenssen, BM et al. (2008): (Table 2) Concentrations of total and free thyroxine and triiodothyronine, 1,25(OH)2D3 and hepatic vitamin D3 in gray (Halichoerus grypus) and ringed (Phoca hispida) seals. https://doi.org/10.1594/PANGAEA.819418