Citation:

s00421-011-1864-9

Name: (Table 1) Characteristics of South Pole personnel according to forced expiratory flow (FEF25-75) response to altitude
Published: 2011
License: https://creativecommons.org/licenses/by/3.0/

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Abstract:

The impact of acute altitude exposure on pulmonary function is variable. A large inter-individual variability in the changes in forced expiratory flows (FEFs) is reported with acute exposure to altitude, which is suggested to represent an interaction between several factors influencing bronchial tone such as changes in gas density, catecholamine stimulation, and mild interstitial edema. This study examined the association between FEF variability, acute mountain sickness (AMS) and various blood markers affecting bronchial tone (endothelin-1, vascular endothelial growth factor (VEGF), catecholamines, angiotensin II) in 102 individuals rapidly transported to the South Pole (2835 m). The mean FEF between 25 and 75% (FEF25-75) and blood markers were recorded at sea level and after the second night at altitude. AMS was assessed using Lake Louise questionnaires. FEF25-75 increased by an average of 12% with changes ranging from -26 to +59% from sea level to altitude. On the second day, AMS incidence was 36% and was higher in individuals with increases in FEF25-75 (41 vs. 22%, P = 0.05). Ascent to altitude induced an increase in endothelin-1 levels, with greater levels observed in individuals with decreased FEF25-75. Epinephrine levels increased with ascent to altitude and the response was six times larger in individuals with decreased FEF25-75. Greater levels of endothelin-1 in individuals with decreased FEF25-75 suggest a response consistent with pulmonary hypertension and/or mild interstitial edema, while epinephrine may be upregulated in these individuals to clear lung fluid through stimulation of beta2-adrenergic receptors.

Project(s):

International Polar Year (2007-2008) (IPY)

Coverage:

Latitude: -90.000000 * Longitude: 0.000000

Minimum Elevation: 2835.0 m * Maximum Elevation: 2835.0 m

Event(s):

South_Pole * Latitude: -90.000000 * Longitude: 0.000000 * Elevation: 2835.0 m * Location: South Pole * Campaign: * Basis: Sampling/drilling ice * Method/Device: Ice drill (ICEDRILL)

Comment:

Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150

Parameter(s):

#	Name	Short Name	Unit	Principal Investigator	Comment
1	Group	Group		Lalande, Sophie
2	Time coverage	Coverage		Lalande, Sophie
3	Age, relative, number of years	Age	a	Lalande, Sophie
4	Age, standard deviation	Age std dev	±	Lalande, Sophie
5	Male	Male	#	Lalande, Sophie
6	Female	Female	#	Lalande, Sophie
7	Elevation, mean	Elev mean	m a.s.l.	Lalande, Sophie	elevation of residence
8	Standard deviation	Std dev	±	Lalande, Sophie	elevation of residence
9	Height	Height	m	Lalande, Sophie
10	Standard deviation	Std dev	±	Lalande, Sophie	height
11	Mass	Mass	kg	Lalande, Sophie	weight
12	Standard deviation	Std dev	±	Lalande, Sophie	mass (weight)
13	Body mass index	BMI	kg/m²	Lalande, Sophie
14	Standard deviation	Std dev	±	Lalande, Sophie	BMI

License:

Creative Commons Attribution 3.0 Unported (CC-BY-3.0)

Size:

42 data points

Data

Download dataset as tab-delimited text — use the following character encoding:

1 Group	2 Coverage	3 Age [a]	4 Age std dev [±]	5 Male [#]	6 Female [#]	7 Elev mean [m a.s.l.] (elevation of residence)	8 Std dev [±] (elevation of residence)	9 Height [m]	10 Std dev [±] (height)	11 Mass [kg] (weight)	12 Std dev [±] (mass (weight))	13 BMI [kg/m²]	14 Std dev [±] (BMI)
Total	2006-2007	35	10	71	31	875	852	1.75	0.09	78.2	14.3	25.3	3.4
Decreased FEF25-75	2006-2007	39	12	17	6	1072	1062	1.77	0.08	79.1	11.3	25.2	2.1
Increased FEF25-75	2006-2007	34	9	54	25	816	775	1.75	0.09	78.0	15.1	25.3	3.7