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Genome Plasticity in Pathogenic and Nonpathogenic Enterobacteria

  • Chapter
Pathogenicity Islands and the Evolution of Pathogenic Microbes

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 264/2))

Abstract

The Enterobacteriaceae comprise a distinct phylogenetic cluster that share a common ancestor with other γ-Proteobacteria. This prokaryotic family comprises 40 genera with 200 species (Garrity 2001). Within this division many representatives live in intimate association with hosts either as pathogens, as commensals or as symbionts (Steinert et al. 2000). The best-studied examples are the entero-bacteria, which comprise the clinically relevant human and animal pathogenic species Escherichia coli, Salmonella enterica, and Shigella spp., as well as Yersinia pestis, Y. pseudotuberculosis and Y. enterocolitica. The entomopathogenic bacterium Photorhabdus luminescens also belongs to the Enterobacteriaceae. This bacterium is unusual in that it combines a symbiotic life style within the guts of nematodes with a pathogenic life style that results in the killing of insects. Among the γ-Proteobacteria there are many species establishing symbiotic interactions mostly with invertebrate hosts, for example with insects, with bioluminescent squid and other marine invertebrates, and with nematodes. The genomes of several pathogens and symbionts have been sequenced recently and work is still in progress. In spite of the diverse manifestations of bacteria-host interactions, there are similar fundamental mechanisms that mediate the interaction and communication between the bacterial and eukaryotic partners (Hentschel et al. 2000; Steinert et al. 2000).

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  1. Institut für Molekulare Infektionsbiologie der Universität Würzburg, Röntgenring 11, 97070, Würzburg, Germany

    U. Dobrindt, U. Hentschel & J. Hacker

  2. Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, Maryland, 21201, USA

    J. B. Kaper

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  1. Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070, Würzburg, Germany

    Jörg Hacker

  2. Center for Vaccine Development, University of Maryland School of Medicine, 685 W. Baltimore Street, 21201, Baltimore, MD, USA

    James B. Kaper

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Dobrindt, U., Hentschel, U., Kaper, J.B., Hacker, J. (2002). Genome Plasticity in Pathogenic and Nonpathogenic Enterobacteria. In: Hacker, J., Kaper, J.B. (eds) Pathogenicity Islands and the Evolution of Pathogenic Microbes. Current Topics in Microbiology and Immunology, vol 264/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56031-6_9

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